Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration - PubMed (original) (raw)
Review
Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration
Jeroen J M Hoozemans et al. Int J Biochem Cell Biol. 2012 Aug.
Abstract
The endoplasmic reticulum (ER) is involved in the folding and maturation of membrane-bound and secreted proteins. Disturbed homeostasis in the ER can lead to accumulation of misfolded proteins, which trigger a stress response called the unfolded protein response (UPR). In neurodegenerative diseases that are classified as tauopathies, activation of the UPR coincides with the pathogenic accumulation of the microtubule associated protein tau. Several lines of evidence indicate that UPR activation contributes to increased levels of phosphorylated tau, a prerequisite for the formation of tau aggregates. Increased understanding of the crosstalk between signaling pathways involved in protein quality control in the ER and tau phosphorylation will support the development of new therapeutic targets that promote neuronal survival.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
- Targeting ASK1 in ER stress-related neurodegenerative diseases.
Homma K, Katagiri K, Nishitoh H, Ichijo H. Homma K, et al. Expert Opin Ther Targets. 2009 Jun;13(6):653-64. doi: 10.1517/14728220902980249. Expert Opin Ther Targets. 2009. PMID: 19456270 Review. - The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum.
Shen X, Zhang K, Kaufman RJ. Shen X, et al. J Chem Neuroanat. 2004 Sep;28(1-2):79-92. doi: 10.1016/j.jchemneu.2004.02.006. J Chem Neuroanat. 2004. PMID: 15363493 Review. - Protein folding stress in neurodegenerative diseases: a glimpse into the ER.
Matus S, Glimcher LH, Hetz C. Matus S, et al. Curr Opin Cell Biol. 2011 Apr;23(2):239-52. doi: 10.1016/j.ceb.2011.01.003. Epub 2011 Jan 31. Curr Opin Cell Biol. 2011. PMID: 21288706 Review. - Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease.
Minamino T, Komuro I, Kitakaze M. Minamino T, et al. Circ Res. 2010 Oct 29;107(9):1071-82. doi: 10.1161/CIRCRESAHA.110.227819. Circ Res. 2010. PMID: 21030724 Review. - Endoplasmic reticulum stress response and neurodegeneration.
Paschen W, Mengesdorf T. Paschen W, et al. Cell Calcium. 2005 Sep-Oct;38(3-4):409-15. doi: 10.1016/j.ceca.2005.06.019. Cell Calcium. 2005. PMID: 16087231 Review.
Cited by
- Inhibition of Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of bFGF in the 6-OHDA-Induced Parkinson's Disease Model.
Cai P, Ye J, Zhu J, Liu D, Chen D, Wei X, Johnson NR, Wang Z, Zhang H, Cao G, Xiao J, Ye J, Lin L. Cai P, et al. Aging Dis. 2016 Jan 17;7(4):336-449. doi: 10.14336/AD.2016.0117. eCollection 2016 Aug. Aging Dis. 2016. PMID: 27493838 Free PMC article. - Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP.
Dametto P, Lakkaraju AK, Bridel C, Villiger L, O'Connor T, Herrmann US, Pelczar P, Rülicke T, McHugh D, Adili A, Aguzzi A. Dametto P, et al. PLoS One. 2015 Feb 6;10(2):e0117412. doi: 10.1371/journal.pone.0117412. eCollection 2015. PLoS One. 2015. PMID: 25658480 Free PMC article. - Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice.
Lindahl M, Chalazonitis A, Palm E, Pakarinen E, Danilova T, Pham TD, Setlik W, Rao M, Võikar V, Huotari J, Kopra J, Andressoo JO, Piepponen PT, Airavaara M, Panhelainen A, Gershon MD, Saarma M. Lindahl M, et al. Neurobiol Dis. 2020 Feb;134:104696. doi: 10.1016/j.nbd.2019.104696. Epub 2019 Nov 26. Neurobiol Dis. 2020. PMID: 31783118 Free PMC article. - Mitochondrial Cholesterol in Alzheimer's Disease and Niemann-Pick Type C Disease.
Torres S, García-Ruiz CM, Fernandez-Checa JC. Torres S, et al. Front Neurol. 2019 Nov 7;10:1168. doi: 10.3389/fneur.2019.01168. eCollection 2019. Front Neurol. 2019. PMID: 31787922 Free PMC article. Review. - Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells.
Hu LW, Yen JH, Shen YT, Wu KY, Wu MJ. Hu LW, et al. PLoS One. 2014 May 20;9(5):e97880. doi: 10.1371/journal.pone.0097880. eCollection 2014. PLoS One. 2014. PMID: 24846311 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical