Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis - PubMed (original) (raw)

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Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis

Teresa Pelaez et al. J Clin Microbiol. 2012 Jul.

Abstract

A voriconazole-resistant isolate of Aspergillus fumigatus was recovered from an immunocompetent patient receiving long-term antifungal therapy for cerebral aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was identified as the cause of the resistance phenotype. This article describes the first isolation of a voriconazole-resistant A. fumigatus isolate from an immunocompetent patient in Spain.

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Figures

Fig 1

Susceptibilities, determined by Etest, of an-azole susceptible strain of A. fumigatus (CM-237), a multiresistant strain (CR019), and the clinical isolate recovered from our patient (TP1362) to voriconazole (VOR), itraconazole (ITC), and posaconazole (POS).

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