Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency - PubMed (original) (raw)

. 2012 Jun 8;336(6086):1306-10.

doi: 10.1126/science.1218632. Epub 2012 May 10.

Giovanni Esposito, Janaka N Edirisinghe, Sven Vilain, Dominik M Haddad, Jan R Slabbaert, Stefanie Van Meensel, Onno Schaap, Bart De Strooper, R Meganathan, Vanessa A Morais, Patrik Verstreken

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Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

Melissa Vos et al. Science. 2012.

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Abstract

Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2). Vitamin K(2) is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function. We found that vitamin K(2) was necessary and sufficient to transfer electrons in Drosophila mitochondria. Heix mutants showed severe mitochondrial defects that were rescued by vitamin K(2), and, similar to ubiquinone, vitamin K(2) transferred electrons in Drosophila mitochondria, resulting in more efficient adenosine triphosphate (ATP) production. Thus, mitochondrial dysfunction was rescued by vitamin K(2) that serves as a mitochondrial electron carrier, helping to maintain normal ATP production.

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