Molecular imaging of adrenal neoplasms - PubMed (original) (raw)

Review

. 2012 Oct 1;106(5):532-42.

doi: 10.1002/jso.23162. Epub 2012 May 24.

Affiliations

Review

Molecular imaging of adrenal neoplasms

Clara C Chen et al. J Surg Oncol. 2012.

Abstract

The adrenal glands are complex structures from which a variety of benign and malignant tumors may arise and are a common site of metastatic disease. Several radiopharmaceuticals are used for imaging the adrenals, including I-123/I-131 metaiodobenzylguanidine (MIBG), norcholesterol derivatives, In-111 pentetreotide and Ga-68 somatostatin analogs, [F-18]fluorodeoxyglucose, [F-18]fluorodopa, [F-18]fluorodopamine, C-11 meta hydroxyephedrine, and C-11/F-18/I-123 Metomidate (MTO) or its analogs. In this review we focus on the role of these reagents in metastatic lesions, cortical neoplasms, pheochromocytoma/paraganglioma, and neuroblastoma (NB).

Copyright © 2012 Wiley Periodicals, Inc.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Fig. 1.

Fig. 1.

Patient with an 8.2 × 5.3 cm adrenal cortical carcinoma showing hypermetabolic activity on FDG in primary tumor with SUVmax of 11.9 (long arrows) and tumor thrombus SUVmax 10.2 (short arrows) confirmed at surgery. Coronal FDG (left panel), CT (middle panel), and fused PET/CT (right panel) images.

Fig. 2.

Fig. 2.

Patient with SDHD and metastatic PHEO/PGL. Imaging with a variety of radiopharmaceutical shows heterogeneity in uptake. MIBG panel (MIP—top, and coronal slice—bottom) shows uptake in bilateral adrenal PHEOs (black arrows). Two foci in lower midline chest are thought to be due to swallowed activity in esophagus, glomus tumor is not visualized. FDG MIP panel shows intense bilateral uptake in the adrenal PHEOs and a right atrial PGL (white arrow). Mild uptake in a right glomus jugulare PGL was also seen (not shown this projection). Foci in mediastinum and upper abdomen (red arrows) represent uptake in brown fat. FDOPA MIP panel shows intense uptake in right glomus jugulare PGL (chevron) and right atrial lesion. Mild uptake was seen in the left adrenal PHEO but not right (not seen in this view). FDA MIP shows intense uptake in bilateral adrenal PHEOs with faint uptake in atrial lesion. Physiologic gallbladder activity is also seen. No intracranial uptake was seen. SRS panel shows In-111 pentetreotide MIP images with intense uptake in the right glomus jugulare tumor and cardiac lesion but no uptake in the bilateral adrenal tumors. Images courtesy of Dr. Karel Pacak, NICHD, NIH.

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