Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits - PubMed (original) (raw)
Meta-Analysis
doi: 10.1038/jhg.2012.60. Epub 2012 May 31.
Tetsutaro Yamaguchi, Chiaki Watanabe, Akira Kawaguchi, Kuniaki Haneji, Mayako Takeda, Yong-Il Kim, Yoko Tomoyasu, Miyuki Watanabe, Hiroki Oota, Tsunehiko Hanihara, Hajime Ishida, Koutaro Maki, Soo-Byung Park, Ryosuke Kimura
Affiliations
- PMID: 22648185
- DOI: 10.1038/jhg.2012.60
Meta-Analysis
Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits
Jeong-Heuy Park et al. J Hum Genet. 2012 Aug.
Abstract
Dental morphology is highly diverse among individuals and between human populations. Although it is thought that genetic factors mainly determine common dental variations, only a few such genetic factors have been identified. One study demonstrated that a nonsynonymous single-nucleotide polymorphism (370V/A, rs3827760) in the ectodysplasin A receptor gene (EDAR) is associated with shoveling and double-shoveling grades of upper first incisors and tooth crown size. Here, we examined the association of EDAR 370V/A with several dental characters in Korean and Japanese subjects. A meta-analysis that combined analyses of Korean and Japanese subjects revealed that the Asian-specific 370A allele is associated with an increase in the grades of shoveling and double shoveling, as previously found. We also showed a highly significant association between EDAR 370V/A genotype and crown size, especially mesiodistal diameters of anterior teeth. Moreover, we found that the 370A allele was associated with the presence of hypoconulids of lower second molars. These results indicated that the EDAR polymorphism is responsible, in part, for the Sinodonty and Sundadonty dichotomy in Asian populations, and clearly demonstrated that the EDAR polymorphism has pleiotropic effects on tooth morphology. As the 370A allele is known to be a most likely target of positive selection in Asian populations, some phenotypes associated with the variant may be 'hitchhiking phenotypes', while others may be actual targets of selection.
Similar articles
- The Eskimo-Aleut Dentition: Crown and Root Morphology.
Scott RG. Scott RG. Acta Stomatol Croat. 2020 Jun;54(2):194-207. doi: 10.15644/asc54/2/10. Acta Stomatol Croat. 2020. PMID: 32801379 Free PMC article. Review. - A common variation in EDAR is a genetic determinant of shovel-shaped incisors.
Kimura R, Yamaguchi T, Takeda M, Kondo O, Toma T, Haneji K, Hanihara T, Matsukusa H, Kawamura S, Maki K, Osawa M, Ishida H, Oota H. Kimura R, et al. Am J Hum Genet. 2009 Oct;85(4):528-35. doi: 10.1016/j.ajhg.2009.09.006. Am J Hum Genet. 2009. PMID: 19804850 Free PMC article. - The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction-diffusion system.
Kataoka K, Fujita H, Isa M, Gotoh S, Arasaki A, Ishida H, Kimura R. Kataoka K, et al. Sci Rep. 2021 Mar 4;11(1):5143. doi: 10.1038/s41598-021-84653-4. Sci Rep. 2021. PMID: 33664401 Free PMC article. - Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant.
Tan J, Peng Q, Li J, Guan Y, Zhang L, Jiao Y, Yang Y, Wang S, Jin L. Tan J, et al. Sci China Life Sci. 2014 May;57(5):510-8. doi: 10.1007/s11427-014-4654-x. Epub 2014 Apr 22. Sci China Life Sci. 2014. PMID: 24752358 - Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.
Mou C, Thomason HA, Willan PM, Clowes C, Harris WE, Drew CF, Dixon J, Dixon MJ, Headon DJ. Mou C, et al. Hum Mutat. 2008 Dec;29(12):1405-11. doi: 10.1002/humu.20795. Hum Mutat. 2008. PMID: 18561327
Cited by
- Biometry of width between labial transitional line angles in anterior teeth: an observational study.
Wen C, Ye H, Chen H, Zhou Y, Huang M, Sun Y. Wen C, et al. J Adv Prosthodont. 2022 Feb;14(1):1-11. doi: 10.4047/jap.2022.14.1.1. Epub 2022 Feb 25. J Adv Prosthodont. 2022. PMID: 35284056 Free PMC article. - Genomic imputation of ancient Asian populations contrasts local adaptation in pre- and post-agricultural Japan.
Cooke NP, Murray M, Cassidy LM, Mattiangeli V, Okazaki K, Kasai K, Gakuhari T, Bradley DG, Nakagome S. Cooke NP, et al. iScience. 2024 May 21;27(6):110050. doi: 10.1016/j.isci.2024.110050. eCollection 2024 Jun 21. iScience. 2024. PMID: 38883821 Free PMC article. - The Eskimo-Aleut Dentition: Crown and Root Morphology.
Scott RG. Scott RG. Acta Stomatol Croat. 2020 Jun;54(2):194-207. doi: 10.15644/asc54/2/10. Acta Stomatol Croat. 2020. PMID: 32801379 Free PMC article. Review. - Population Genomics of Human Adaptation.
Lachance J, Tishkoff SA. Lachance J, et al. Annu Rev Ecol Evol Syst. 2013 Nov;44:123-143. doi: 10.1146/annurev-ecolsys-110512-135833. Annu Rev Ecol Evol Syst. 2013. PMID: 25383060 Free PMC article. - Modeling recent human evolution in mice by expression of a selected EDAR variant.
Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC. Kamberov YG, et al. Cell. 2013 Feb 14;152(4):691-702. doi: 10.1016/j.cell.2013.01.016. Cell. 2013. PMID: 23415220 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials