Liver autophagy: physiology and pathology - PubMed (original) (raw)
Review
doi: 10.1093/jb/mvs059. Epub 2012 Jun 1.
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- PMID: 22661765
- DOI: 10.1093/jb/mvs059
Review
Liver autophagy: physiology and pathology
Masaaki Komatsu. J Biochem. 2012 Jul.
Abstract
Autophagy has long been thought of as a bulk degradation system in which cytoplasmic components are sequestered by double-membrane structures called autophagosomes, and the contents are then degraded after autophagosomes fuse with lysosomes. Genetic experiments in yeast identified a set of Autophagy-related (ATG) genes that are essential for autophagy. We have since elucidated many of the molecular underpinnings of autophagy and the physiologic roles of these processes in various systems. This review summarizes the physiologic roles of autophagy with a particular focus on liver autophagy based on analyses of knockout mice lacking Atg genes.
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