Mitochondrial anti-viral immunity - PubMed (original) (raw)
Review
Mitochondrial anti-viral immunity
Naima Zemirli et al. Int J Biochem Cell Biol. 2012 Sep.
Abstract
In the cytosol, the sensing of RNA viruses by the RIG-I-like receptors (RLRs) triggers a complex signaling cascade where the mitochondrial antiviral signaling protein (MAVS) plays a crucial role in orchestrating the innate host response through the induction of antiviral and inflammatory responses. Hence, in addition to their known roles in the metabolic processes and the control of programmed cell death, mitochondria are now emerging as a fundamental hub for innate anti-viral immunity. This review summarizes the findings related to the MAVS adapter and mitochondria in the innate immune response to RNA viruses.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
- Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.
Belgnaoui SM, Paz S, Hiscott J. Belgnaoui SM, et al. Curr Opin Immunol. 2011 Oct;23(5):564-72. doi: 10.1016/j.coi.2011.08.001. Epub 2011 Aug 22. Curr Opin Immunol. 2011. PMID: 21865020 Review. - Mitochondrial dynamics and the innate antiviral immune response.
Pourcelot M, Arnoult D. Pourcelot M, et al. FEBS J. 2014 Sep;281(17):3791-802. doi: 10.1111/febs.12940. Epub 2014 Aug 11. FEBS J. 2014. PMID: 25051991 Review. - MAVS: a new weapon in the fight against viral infections.
Boga JA, de Oña M, Melon S, Alvarez-Arguelles ME, Morilla A, Coto-Montes A. Boga JA, et al. Recent Pat Endocr Metab Immune Drug Discov. 2013 May;7(2):115-9. doi: 10.2174/1872214811307020004. Recent Pat Endocr Metab Immune Drug Discov. 2013. PMID: 23432157 Review. - The role of mitochondria in the mammalian antiviral defense system.
Scott I. Scott I. Mitochondrion. 2010 Jun;10(4):316-20. doi: 10.1016/j.mito.2010.02.005. Epub 2010 Mar 2. Mitochondrion. 2010. PMID: 20206303 Free PMC article. Review.
Cited by
- RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux.
da Costa LS, Outlioua A, Anginot A, Akarid K, Arnoult D. da Costa LS, et al. Cell Death Dis. 2019 Apr 25;10(5):346. doi: 10.1038/s41419-019-1579-0. Cell Death Dis. 2019. PMID: 31024004 Free PMC article. - Epigenetics of Subcellular Structure Functioning in the Origin of Risk or Resilience to Comorbidity of Neuropsychiatric and Cardiometabolic Disorders.
Zapata-Martín Del Campo CM, Martínez-Rosas M, Guarner-Lans V. Zapata-Martín Del Campo CM, et al. Int J Mol Sci. 2018 May 14;19(5):1456. doi: 10.3390/ijms19051456. Int J Mol Sci. 2018. PMID: 29757967 Free PMC article. Review. - Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.
Huang B, Zhang L, Du Y, Xu F, Li L, Zhang G. Huang B, et al. Sci Rep. 2017 Aug 15;7(1):8217. doi: 10.1038/s41598-017-08566-x. Sci Rep. 2017. PMID: 28811654 Free PMC article. - Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance.
Riquelme SA, Carreño LJ, Espinoza JA, Mackern-Oberti JP, Alvarez-Lobos MM, Riedel CA, Bueno SM, Kalergis AM. Riquelme SA, et al. Immunology. 2016 Sep;149(1):1-12. doi: 10.1111/imm.12605. Epub 2016 Apr 1. Immunology. 2016. PMID: 26938875 Free PMC article. Review. - Mitochondria, energetics, epigenetics, and cellular responses to stress.
Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Shaughnessy DT, et al. Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. Environ Health Perspect. 2014. PMID: 25127496 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous