One core, two shells: bacterial and eukaryotic ribosomes - PubMed (original) (raw)

Review

. 2012 Jun 5;19(6):560-7.

doi: 10.1038/nsmb.2313.

Affiliations

Review

One core, two shells: bacterial and eukaryotic ribosomes

Sergey Melnikov et al. Nat Struct Mol Biol. 2012.

Abstract

Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.

PubMed Disclaimer

References

    1. Nature. 2008 Mar 6;452(7183):108-11 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 - PubMed
    1. Science. 2011 May 20;332(6032):981-4 - PubMed
    1. Mol Microbiol. 2007 Nov;66(4):1039-50 - PubMed
    1. Biochimie. 1983 Jul;65(7):427-36 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources