Intermuscular adipose tissue is muscle specific and associated with poor functional performance - PubMed (original) (raw)

Intermuscular adipose tissue is muscle specific and associated with poor functional performance

Lori J Tuttle et al. J Aging Res. 2012.

Abstract

Purpose. People with obesity, diabetes, and peripheral neuropathy have high levels of intermuscular adipose tissue (IMAT) volume which has been inversely related to physical function. We determined if IMAT is muscle specific, if calf IMAT is different between a healthy obese group (HO), a group with diabetes mellitus (D), and a group with diabetes mellitus and peripheral neuropathy (DN), and if IMAT volume or the ratio of IMAT/muscle volume is related to physical function in these groups. Methods. 10 healthy obese people, 11 with type 2 diabetes, 24 with diabetes and peripheral neuropathy, had assessments of muscle morphology, physical function and muscle performance. Results. The gastrocnemius muscle had a higher ratio of IMAT/muscle volume than any other muscle or compartment. There were no differences between groups in calf muscle or IMAT volumes. Calf IMAT was inversely related to physical performance on the 6-minute walk test (r = -0.47) and physical performance test (r = -0.36). IMAT/muscle volume was inversely related to physical performance (PPT, r = -0.44; 6 MW r = -0.48; stair power, r = -0.30). Conclusions. IMAT accumulation varies in calf muscles, is highest in the gastrocnemius muscle, and is associated with poor physical performance.

PubMed Disclaimer

Figures

Figure 1

Figure 1

(a) MRI image of calf with bone removed. (b) Subcutaneous adipose tissue removed. (c) Calf divided into 5 compartments (anterior, lateral, deep, gastrocnemius, and soleus).

Similar articles

Cited by

References

    1. Hilton TN, Tuttle LJ, Bohnert KL, Mueller MJ, Sinacore DR. Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Physical Therapy. 2008;88(11):1336–1344. - PMC - PubMed
    1. Lawler JM, Song W, Demaree SR. Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle. Free Radical Biology and Medicine. 2003;35(1):9–16. - PubMed
    1. Ruan XY, Gallagher D, Harris T, et al. Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images. Journal of Applied Physiology. 2007;102(2):748–754. - PMC - PubMed
    1. Goodpaster BH, Krishnaswami S, Resnick H, et al. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care. 2003;26(2):372–379. - PubMed
    1. Goodpaster BH, Thaete FL, Kelley DE. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. American Journal of Clinical Nutrition. 2000;71(4):885–892. - PubMed

LinkOut - more resources