HIV-1 antiretroviral resistance: scientific principles and clinical applications - PubMed (original) (raw)

Fig. 4

Summary of protease inhibitor (PI) drug-resistance mutations. Mutations are represented by their numeric position and amino acid letter code. The amino acid of the consensus wild-type sequence is represented by letters in the top row, while the amino acids of the mutations are below. Bold and underlining indicates significant phenotypic or clinical resistance (probable contraindication); bold indicates significant contribution to resistance; plain text indicates primarily accessory contribution to resistance. Common accessory mutations: L10IVF, V11I, K20TVI, L23I, L24IF, L33F, K43T, F53L, Q58E, A71VTIL, G73STCA, T74PS, N83D, L89V. Hypersusceptibility mutations: I50L increases susceptibility to all PIs except ATV. I50V and I54L to TPV. L76V to ATV, SQV and TPV. N88S to FPV. Genotypic susceptibility scores: DRV (Tibotec):11I, 32I, 33F, 47V, 50V, 54LM, 74P, 76V, 84V, 89V; <3 susceptible; 3–4 low/intermediate; >4 high level. TPV (Boehringer): 47V (+4), 74P (+4), 82LT(+4), 83D (4), 58E (3), 84V (3), 36I (2), 43T (2), 54AMV (2), 10V (1), 33F (1), 46L (1), 24I (−2), 76V (−2), 50L/V (−4), 54L (−6); <4 susceptible; 5–10 intermediate; >10 high level. Refer to table I for a full list of drug name abbreviations and definitions. Adapted from the Stanford University HIV Drug Resistance Database.[40] Cons = consensus wild-type.