Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3 - PubMed (original) (raw)
Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3
Tadahide Furuno et al. J Neuroimmunol. 2012.
Abstract
Cell adhesion molecule 1 (CADM1) on mast cells promotes attachment and communication with neurons by homophilic binding. However, we found that mast cell CADM1 was responsible for both the attachment of mast cells to dorsal root ganglia (DRG) neurites and their calcium responses to activated DRG neurites, despite the low expression of CADM1 in DRG. Instead, nectin-3 was expressed on DRG neurons and localized to regions of cell-cell contact. A neutralizing antibody to nectin-3 inhibited both mast cell attachment and subsequent calcium responses. This suggests that heterophilic binding between CADM1 and nectin-3 mediates functional DRG-mast cell interactions in vitro.
Copyright © 2012 Elsevier B.V. All rights reserved.
Similar articles
- Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis.
Hagiyama M, Inoue T, Furuno T, Iino T, Itami S, Nakanishi M, Asada H, Hosokawa Y, Ito A. Hagiyama M, et al. Br J Dermatol. 2013 Apr;168(4):771-8. doi: 10.1111/bjd.12108. Br J Dermatol. 2013. PMID: 23106683 - Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1.
Hagiyama M, Furuno T, Hosokawa Y, Iino T, Ito T, Inoue T, Nakanishi M, Murakami Y, Ito A. Hagiyama M, et al. J Immunol. 2011 May 15;186(10):5983-92. doi: 10.4049/jimmunol.1002244. Epub 2011 Apr 11. J Immunol. 2011. PMID: 21482734 - Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.
Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A. Koma Y, et al. Gastroenterology. 2008 May;134(5):1544-54. doi: 10.1053/j.gastro.2008.01.081. Epub 2008 Feb 10. Gastroenterology. 2008. PMID: 18471525 - Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1.
Ito A, Hagiyama M, Oonuma J. Ito A, et al. J Smooth Muscle Res. 2008 Apr;44(2):83-93. doi: 10.1540/jsmr.44.83. J Smooth Muscle Res. 2008. PMID: 18552455 Review. - Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule.
Ito A, Oonuma J. Ito A, et al. J Pharmacol Sci. 2006 Sep;102(1):1-5. doi: 10.1254/jphs.cpj06014x. Epub 2006 Aug 26. J Pharmacol Sci. 2006. PMID: 16936456 Review.
Cited by
- [Neuroimmunology of allergic rhinitis part 2 : Interactions of neurons and immune cells and neuroimmunological units].
Klimek L, Werminghaus P, Bergmann C, Hagemann J, Huppertz T, Bärhold F, Klimek F, Dziadziulia K, Casper I, Polk ML, Cuevas M, Gröger M, Becker S. Klimek L, et al. HNO. 2023 Jun;71(6):413-421. doi: 10.1007/s00106-023-01304-y. Epub 2023 May 12. HNO. 2023. PMID: 37171595 German. - Mechanisms underlying the neuronal-based symptoms of allergy.
Undem BJ, Taylor-Clark T. Undem BJ, et al. J Allergy Clin Immunol. 2014 Jun;133(6):1521-34. doi: 10.1016/j.jaci.2013.11.027. Epub 2014 Jan 13. J Allergy Clin Immunol. 2014. PMID: 24433703 Free PMC article. Review. - Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S. Nakamura S, et al. PLoS One. 2017 Apr 17;12(4):e0175632. doi: 10.1371/journal.pone.0175632. eCollection 2017. PLoS One. 2017. PMID: 28414795 Free PMC article. - Integrated single-cell analyses decode the developmental landscape of the human fetal spine.
Yu H, Tang D, Wu H, Li C, Lu Y, He F, Zhang X, Yang Y, Shi W, Hu W, Zeng Z, Dai W, Ou M, Dai Y. Yu H, et al. iScience. 2022 Jun 27;25(7):104679. doi: 10.1016/j.isci.2022.104679. eCollection 2022 Jul 15. iScience. 2022. PMID: 35832888 Free PMC article. - Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation.
Siiskonen H, Harvima I. Siiskonen H, et al. Front Cell Neurosci. 2019 Sep 18;13:422. doi: 10.3389/fncel.2019.00422. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31619965 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous