Transport protein genes in the murine MHC: possible implications for antigen processing - PubMed (original) (raw)

Comparative Study

. 1990 Dec 21;250(4988):1723-6.

doi: 10.1126/science.2270487.

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Comparative Study

Transport protein genes in the murine MHC: possible implications for antigen processing

J J Monaco et al. Science. 1990.

Abstract

T lymphocyte activation requires recognition by the T cell of peptide fragments of foreign antigen bound to a self major histocompatibility complex (MHC) molecule. Genetic evidence suggests that part of the class II region of the MHC influences the expression, in trans, of MHC class I antigens on the cell surface, by regulating the availability of peptides that bind to and stabilize the class I molecule. Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent transport of a variety of substrates across cell membranes. Thus, these MHC-linked transport protein genes may be involved in transporting antigen, or peptide fragments thereof, from the cytoplasm into a membrane-bounded compartment containing newly synthesized MHC molecules.

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