SH3 domain ligand binding: What's the consensus and where's the specificity? - PubMed (original) (raw)
Review
. 2012 Aug 14;586(17):2609-14.
doi: 10.1016/j.febslet.2012.04.042. Epub 2012 May 2.
Affiliations
- PMID: 22710157
- DOI: 10.1016/j.febslet.2012.04.042
Free article
Review
SH3 domain ligand binding: What's the consensus and where's the specificity?
Kalle Saksela et al. FEBS Lett. 2012.
Free article
Abstract
An increasing number of SH3 domain-ligand interactions continue to be described that involve the conserved peptide-binding surface of SH3, but structurally deviate substantially from canonical docking of consensus motif-containing SH3 ligands. Indeed, it appears that that the relative frequency and importance of these types of interactions may have been underestimated. Instead of atypical, we propose referring to such peptides as type I or II (depending on the binding orientation) non-consensus ligands. Here we discuss the structural basis of non-consensus SH3 ligand binding and the dominant role of the SH3 domain specificity zone in selective target recognition, and review some of the best-characterized examples of such interactions.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
- Structural basis of PxxDY motif recognition in SH3 binding.
Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P. Aitio O, et al. J Mol Biol. 2008 Sep 26;382(1):167-78. doi: 10.1016/j.jmb.2008.07.008. Epub 2008 Jul 11. J Mol Biol. 2008. PMID: 18644376 - Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain.
Brasher BB, Roumiantsev S, Van Etten RA. Brasher BB, et al. Oncogene. 2001 Nov 22;20(53):7744-52. doi: 10.1038/sj.onc.1204978. Oncogene. 2001. PMID: 11753652 - SH3 domains and drug design: ligands, structure, and biological function.
Dalgarno DC, Botfield MC, Rickles RJ. Dalgarno DC, et al. Biopolymers. 1997;43(5):383-400. doi: 10.1002/(SICI)1097-0282(1997)43:5<383::AID-BIP4>3.0.CO;2-R. Biopolymers. 1997. PMID: 9566119 Review. - Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domains.
Teyra J, Sidhu SS, Kim PM. Teyra J, et al. FEBS Lett. 2012 Aug 14;586(17):2631-7. doi: 10.1016/j.febslet.2012.05.043. Epub 2012 Jun 9. FEBS Lett. 2012. PMID: 22691579 Review.
Cited by
- CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.
Poissonnier A, Sanséau D, Le Gallo M, Malleter M, Levoin N, Viel R, Morere L, Penna A, Blanco P, Dupuy A, Poizeau F, Fautrel A, Seneschal J, Jouan F, Ritz J, Forcade E, Rioux N, Contin-Bordes C, Ducret T, Vacher AM, Barrow PA, Flynn RJ, Vacher P, Legembre P. Poissonnier A, et al. Immunity. 2016 Jul 19;45(1):209-23. doi: 10.1016/j.immuni.2016.06.028. Immunity. 2016. PMID: 27438772 Free PMC article. - Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors.
Andersen KR, Onischenko E, Tang JH, Kumar P, Chen JZ, Ulrich A, Liphardt JT, Weis K, Schwartz TU. Andersen KR, et al. Elife. 2013 Jun 11;2:e00745. doi: 10.7554/eLife.00745. Elife. 2013. PMID: 23795296 Free PMC article. - Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs.
Pinet L, Assrir N, van Heijenoort C. Pinet L, et al. Biomolecules. 2021 Nov 14;11(11):1690. doi: 10.3390/biom11111690. Biomolecules. 2021. PMID: 34827688 Free PMC article. Review. - High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1.
Liao TJ, Jang H, Nussinov R, Fushman D. Liao TJ, et al. J Am Chem Soc. 2020 Feb 19;142(7):3401-3411. doi: 10.1021/jacs.9b10710. Epub 2020 Feb 4. J Am Chem Soc. 2020. PMID: 31970984 Free PMC article. - Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia.
Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ. Butt E, et al. Cells. 2020 Feb 14;9(2):444. doi: 10.3390/cells9020444. Cells. 2020. PMID: 32075106 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources