[Post-thymus transplant vitiligo in a child with Foxn1 deficiency] - PubMed (original) (raw)
Case Reports
. 2012 Jun;139(6-7):468-71.
doi: 10.1016/j.annder.2012.03.014. Epub 2012 Apr 17.
[Article in French]
Affiliations
- PMID: 22721479
- DOI: 10.1016/j.annder.2012.03.014
Case Reports
[Post-thymus transplant vitiligo in a child with Foxn1 deficiency]
[Article in French]
E Levy et al. Ann Dermatol Venereol. 2012 Jun.
Abstract
Background: Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma.
Case report: A 3-year-old boy underwent thymus transplantation at the age of 9 months for Foxn1 deficiency. He had developed urticaria and autoimmune hypothyroidism after thymus grafting. On examination, he had universal non-scarring alopecia, nail changes (atrophy, partial onycholysis and longitudinal grooves) and leucoderma on both big toes.
Discussion: This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. The pathogenic hypotheses discussed were post-graft vitiligo and leucoderma induced by Foxn1 deficiency.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
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