Prefrontal hyperactivity in older people during motor planning - PubMed (original) (raw)
Prefrontal hyperactivity in older people during motor planning
Marika Berchicci et al. Neuroimage. 2012 Sep.
Abstract
The aim of this study was to assess the influence of age-related changes in cortical activity related to the motor preparation involved in simple- and discriminative-reaction tasks. To distinguish between age effects on motor planning and stimulus processing, both movement- and stimulus-locked event related potentials (ERPs) were investigated in 14 younger, 14 middle-aged, and 14 older adults (mean ages 24.4, 49, and 70 years, respectively). The novel results of the present study are the prefrontal over-recruitment observed in older adults in movement-related cortical potentials (MRCPs) and the differential pattern of aging effects observed at behavioral and at electrophysiological level between middle-aged and older adults. Overall, the following results were observed: (i) behavioral results confirmed the well-known slowing of responses in aging people, which were associated with optimal accuracy; (ii) the age-related differences in cortical activity underlying the generation of voluntary movements in response to external stimuli were more pronounced for the motor planning than the stimulus processing stage; (iii) the source and the time-course analysis of the over-recruitment in the older adults indicated tonic involvement of prefrontal areas regardless of task complexity; and (iv) middle-aged adults showed a 'young adult-like' behavioral speed, but an 'older adult-like' overactivation of prefrontal areas. In summary, to reach the same accuracy, older subjects prepared the action with greater anticipation and higher cost, as indexed by the earlier latency onset and larger prefrontal cortical activation.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
- The effect of aging on movement related cortical potentials during a face naming task.
Buján A, Lindín M, Díaz F. Buján A, et al. Int J Psychophysiol. 2010 Nov;78(2):169-78. doi: 10.1016/j.ijpsycho.2010.07.006. Epub 2010 Aug 10. Int J Psychophysiol. 2010. PMID: 20708041 - Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sample.
Lamar M, Yousem DM, Resnick SM. Lamar M, et al. Neuroimage. 2004 Apr;21(4):1368-76. doi: 10.1016/j.neuroimage.2003.11.018. Neuroimage. 2004. PMID: 15050562 - Intracerebral ERD/ERS in voluntary movement and in cognitive visuomotor task.
Rektor I, Sochůrková D, Bocková M. Rektor I, et al. Prog Brain Res. 2006;159:311-30. doi: 10.1016/S0079-6123(06)59021-1. Prog Brain Res. 2006. PMID: 17071240 - Information processing for motor performance in aging adults.
Light KE. Light KE. Phys Ther. 1990 Dec;70(12):820-6. doi: 10.1093/ptj/70.12.820. Phys Ther. 1990. PMID: 2236225 Review. - Motor control and aging: links to age-related brain structural, functional, and biochemical effects.
Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, Gwin JT, Kwak Y, Lipps DB. Seidler RD, et al. Neurosci Biobehav Rev. 2010 Apr;34(5):721-33. doi: 10.1016/j.neubiorev.2009.10.005. Epub 2009 Oct 20. Neurosci Biobehav Rev. 2010. PMID: 19850077 Free PMC article. Review.
Cited by
- Attempting to counteract vigilance decrement in older adults with brain stimulation.
Löffler BS, Stecher HI, Meiser A, Fudickar S, Hein A, Herrmann CS. Löffler BS, et al. Front Neuroergon. 2023 Dec 12;4:1201702. doi: 10.3389/fnrgo.2023.1201702. eCollection 2023. Front Neuroergon. 2023. PMID: 38234473 Free PMC article. - Temporal spectral evolution of pre-stimulus brain activity in visual and visuomotor tasks.
Sarrias-Arrabal E, Berchicci M, Bianco V, Vázquez-Marrufo M, Perri RL, Di Russo F. Sarrias-Arrabal E, et al. Cogn Neurodyn. 2023 Dec;17(6):1433-1446. doi: 10.1007/s11571-022-09910-2. Epub 2022 Nov 30. Cogn Neurodyn. 2023. PMID: 37969946 Free PMC article. - Investigating the effects of the aging brain on real tool use performance-an fMRI study.
Seifert C, Zhao J, Brandi ML, Kampe T, Hermsdörfer J, Wohlschläger A. Seifert C, et al. Front Aging Neurosci. 2023 Aug 22;15:1238731. doi: 10.3389/fnagi.2023.1238731. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37674783 Free PMC article. - Readiness potential reflects the intention of sit-to-stand movement.
Singh B, Natsume K. Singh B, et al. Cogn Neurodyn. 2023 Jun;17(3):605-620. doi: 10.1007/s11571-022-09864-5. Epub 2022 Aug 8. Cogn Neurodyn. 2023. PMID: 37265646 Free PMC article. - Electrophysiological Correlates of Different Proactive Controls during Response Competition and Inhibition Tasks.
Berchicci M, Bianco V, Hamidi H, Fiorini L, Di Russo F. Berchicci M, et al. Brain Sci. 2023 Mar 7;13(3):455. doi: 10.3390/brainsci13030455. Brain Sci. 2023. PMID: 36979265 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical