Effects of aerobic exercise intensity on abdominal and thigh adipose tissue and skeletal muscle attenuation in overweight women with type 2 diabetes mellitus - PubMed (original) (raw)
Effects of aerobic exercise intensity on abdominal and thigh adipose tissue and skeletal muscle attenuation in overweight women with type 2 diabetes mellitus
Ji Yeon Jung et al. Diabetes Metab J. 2012 Jun.
Abstract
Background: We investigated the effects of exercise intensity on abdominal and mid-thigh adipose tissue, attenuation of skeletal muscle, and insulin sensitivity in overweight women with type 2 diabetes mellitus (T2DM).
Methods: Twenty-eight patients were randomly assigned to control (CG, n=12), moderate intensity exercise (MEG, n=8), or vigorous intensity exercise (VEG, n=8) group. Subjects in both exercise groups completed a 12-week exercise program (MEG, 3.6 to 5.2 METs; VEG, ≥5.2 METs) that was monitored by accelerometers. We assessed body mass index (BMI), total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), mid-thigh intramuscular adipose tissue (TIMAT), total skeletal muscle (TTM), low density skeletal muscle (TLDM), and normal density skeletal muscle (TNDM) using computed tomography, and measured insulin sensitivity with an insulin tolerance test (K(ITT)), before and after the intervention.
Results: At baseline, the mean age was 53.8±7.9 years, duration of diabetes was 3.8±2.3 years, and BMI was 26.6±2.6 kg/m(2). After 12 weeks, the percent change (%C) in BMI, TIMAT, and TLDM were not different among three groups. However, %C in TFA and VFA were significantly reduced in MEG compared to CG (P=0.026 and P=0.008, respectively). %C SFA was significantly reduced in VEG compared to CG (P=0.038) and %C TTM, TNDM, and K(ITT) were significantly increased in VEG compared to the CG (P=0.044, P=0.007, and P=0.016, respectively).
Conclusion: Although there was no difference in the change in BMI among groups, TFA and VFA were more reduced in MEG, and only VEG increased TTM, TNDM, and insulin sensitivity compared to CG.
Keywords: Abdominal fat; Attenuation of skeletal muscle; Diabetes mellitus, type 2; Exercise intensity; Mid-thigh adipose tissue.
Conflict of interest statement
No potential conflict of interest relevant to this article was reported.
Figures
Fig. 1
Change in abdominal fat (A), mid-thigh fat (B), and mid-thigh muscle (C) after 3-month intervention among 3 groups. TFA, total fat area; VFA, visceral fat area; SFA, subcutaneous fat area; TSFA, mid-thigh subcutaneous fat area; TFFA, mid-thigh subfascial fat area; TIMAT, mid-thigh intramuscular adipose tissue; TTM, mid-thigh total muscle; TLDM, mid-thigh low density muscle; TNDM, mid-thigh normal density muscle; CG, control group; MEG, moderate intensity exercise group; VEG, vigorous intensity exercise group. a_P_ value <0.05 compared to control group.
Fig. 2
Change in insulin sensitivity after 3-month intervention among 3 groups. CG, control group; MEG, moderate intensity exercise group; VEG, vigorous intensity exercise group. a_P_ value <0.05 compared to control group.
Similar articles
- Visceral adiposity and inflammatory bowel disease.
Rowan CR, McManus J, Boland K, O'Toole A. Rowan CR, et al. Int J Colorectal Dis. 2021 Nov;36(11):2305-2319. doi: 10.1007/s00384-021-03968-w. Epub 2021 Jun 9. Int J Colorectal Dis. 2021. PMID: 34104989 Review. - Effects of aerobic exercise on abdominal fat, thigh muscle mass and muscle strength in type 2 diabetic subject.
Kwon HR, Min KW, Ahn HJ, Seok HG, Koo BK, Kim HC, Han KA. Kwon HR, et al. Korean Diabetes J. 2010 Feb;34(1):23-31. doi: 10.4093/kdj.2010.34.1.23. Epub 2010 Feb 28. Korean Diabetes J. 2010. PMID: 20532017 Free PMC article. - Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes.
Jung JY, Min KW, Ahn HJ, Kwon HR, Lee JH, Park KS, Han KA. Jung JY, et al. Diabetes Metab J. 2014 Dec;38(6):439-48. doi: 10.4093/dmj.2014.38.6.439. Epub 2014 Dec 15. Diabetes Metab J. 2014. PMID: 25541607 Free PMC article. - The compensatory effect of exercise on physical activity and energy intake in young men with overweight: The EFECT randomised controlled trial.
Paravidino VB, Mediano MFF, Crochemore-Silva I, da Cruz VL, Antunes MML, Beaulieu K, Gibbons C, Finlayson G, Blundell JE, Sichieri R. Paravidino VB, et al. Physiol Behav. 2021 Feb 1;229:113249. doi: 10.1016/j.physbeh.2020.113249. Epub 2020 Nov 20. Physiol Behav. 2021. PMID: 33221391 Clinical Trial. - Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials.
Hibi M, Takase H, Iwasaki M, Osaki N, Katsuragi Y. Hibi M, et al. Nutr Res. 2018 Jul;55:1-10. doi: 10.1016/j.nutres.2018.03.012. Epub 2018 Mar 23. Nutr Res. 2018. PMID: 29914623 Review.
Cited by
- The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression.
Kazeminasab F, Bahrami Kerchi A, Behzadnejad N, Belyani S, Rosenkranz SK, Bagheri R, Dutheil F. Kazeminasab F, et al. J Clin Med. 2024 Aug 23;13(17):5005. doi: 10.3390/jcm13175005. J Clin Med. 2024. PMID: 39274218 Free PMC article. Review. - Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function.
Erlandson KM, Umbleja T, Lu MT, Taron J, Ribaudo HJ, Overton ET, Presti RM, Haas DW, Sax PE, Yin MT, Zhai BK, Louis R, Upadhyay N, Eslami P, Douglas PS, Zanni MV, Fitch KV, Fulda ES, Fichtenbaum CJ, Malvestutto CD, Grinspoon SK, Brown TT. Erlandson KM, et al. J Acquir Immune Defic Syndr. 2023 Oct 1;94(2):174-184. doi: 10.1097/QAI.0000000000003244. J Acquir Immune Defic Syndr. 2023. PMID: 37368931 Free PMC article. Clinical Trial. - Dose-response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials.
Recchia F, Leung CK, Yu AP, Leung W, Yu DJ, Fong DY, Montero D, Lee CH, Wong SHS, Siu PM. Recchia F, et al. Br J Sports Med. 2023 Aug;57(16):1035-1041. doi: 10.1136/bjsports-2022-106304. Epub 2023 Jan 20. Br J Sports Med. 2023. PMID: 36669870 Free PMC article. Review. - Intermuscular adipose tissue in metabolic disease.
Goodpaster BH, Bergman BC, Brennan AM, Sparks LM. Goodpaster BH, et al. Nat Rev Endocrinol. 2023 May;19(5):285-298. doi: 10.1038/s41574-022-00784-2. Epub 2022 Dec 23. Nat Rev Endocrinol. 2023. PMID: 36564490 Review. - Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta-analysis.
Armstrong A, Jungbluth Rodriguez K, Sabag A, Mavros Y, Parker HM, Keating SE, Johnson NA. Armstrong A, et al. Obes Rev. 2022 Aug;23(8):e13446. doi: 10.1111/obr.13446. Epub 2022 Apr 5. Obes Rev. 2022. PMID: 35383401 Free PMC article. Review.
References
- Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB Health, Aging and Body Composition Study. Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am J Epidemiol. 2004;160:741–749. - PubMed
- Nishida Y, Higaki Y, Tokuyama K, Fujimi K, Kiyonaga A, Shindo M, Sato Y, Tanaka H. Effect of mild exercise training on glucose effectiveness in healthy men. Diabetes Care. 2001;24:1008–1013. - PubMed
- Sipila S, Elorinne M, Alen M, Suominen H, Kovanen V. Effects of strength and endurance training on muscle fibre characteristics in elderly women. Clin Physiol. 1997;17:459–474. - PubMed
- Mourier A, Gautier JF, De Kerviler E, Bigard AX, Villette JM, Garnier JP, Duvallet A, Guezennec CY, Cathelineau G. Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements. Diabetes Care. 1997;20:385–391. - PubMed
- Giannopoulou I, Ploutz-Snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S, Kanaley JA. Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab. 2005;90:1511–1518. - PubMed
LinkOut - more resources
Full Text Sources