Oxidized low density lipoprotein, stem cells, and atherosclerosis - PubMed (original) (raw)

Review

Oxidized low density lipoprotein, stem cells, and atherosclerosis

Hui Yang et al. Lipids Health Dis. 2012.

Abstract

Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.

PubMed Disclaimer

Figures

Figure 1

The molecular events included in the direct toxic effects of ox-LDL on stem cells. ?: whether receptors mediate phagocytosis of ox-LDL in MSCs is not clear; →: positive effects; ⊥: negative effects.

Similar articles

• Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.
  Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL. Yu P, et al. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21. Arterioscler Thromb Vasc Biol. 2018. PMID: 29162602 Free PMC article.
• The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis.
  Mehta JL. Mehta JL. Can J Cardiol. 2004 Aug;20 Suppl B:32B-36B. Can J Cardiol. 2004. PMID: 15309203 Review.
• Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases.
  Svanteson M, Rollefstad S, Kløw NE, Hisdal J, Ikdahl E, Sexton J, Haig Y, Semb AG. Svanteson M, et al. PLoS One. 2019 Dec 12;14(12):e0226479. doi: 10.1371/journal.pone.0226479. eCollection 2019. PLoS One. 2019. PMID: 31830762 Free PMC article.
• CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications.
  Tian K, Xu Y, Sahebkar A, Xu S. Tian K, et al. Curr Atheroscler Rep. 2020 Aug 9;22(10):59. doi: 10.1007/s11883-020-00870-8. Curr Atheroscler Rep. 2020. PMID: 32772254 Review.
• Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation.
  Sezer ED, Sozmen EY, Nart D, Onat T. Sezer ED, et al. Vasc Health Risk Manag. 2011;7:333-43. doi: 10.2147/VHRM.S17781. Epub 2011 Jun 1. Vasc Health Risk Manag. 2011. PMID: 21731885 Free PMC article.

Cited by

• Baccaurea angulata fruit inhibits lipid peroxidation and induces the increase in antioxidant enzyme activities.
  Mikail MA, Ahmed IA, Ibrahim M, Hazali N, Abdul Rasad MS, Abdul Ghani R, Hashim R, Abdul Wahab R, Jahuari Arief S, Md Isa ML, Draman S, Adros Yahya MN. Mikail MA, et al. Eur J Nutr. 2016 Jun;55(4):1435-44. doi: 10.1007/s00394-015-0961-7. Epub 2015 Jun 20. Eur J Nutr. 2016. PMID: 26091909
• Prevention of Oxidized Low Density Lipoprotein-Induced Endothelial Cell Injury by DA-PLGA-PEG-cRGD Nanoparticles Combined with Ultrasound.
  Li Z, Huang H, Huang L, Du L, Sun Y, Duan Y. Li Z, et al. Int J Mol Sci. 2017 Apr 13;18(4):815. doi: 10.3390/ijms18040815. Int J Mol Sci. 2017. PMID: 28406431 Free PMC article.
• HDL-Associated Paraoxonase 1 as a Bridge between Postmenopausal Osteoporosis and Cardiovascular Disease.
  Eren E, Ellidag HY, Aydin O, Yılmaz N. Eren E, et al. Chonnam Med J. 2014 Dec;50(3):75-81. doi: 10.4068/cmj.2014.50.3.75. Epub 2014 Dec 17. Chonnam Med J. 2014. PMID: 25568841 Free PMC article. Review.
• IRF2BP2 prevents ox-LDL-induced inflammation and EMT in endothelial cells via regulation of KLF2.
  Jiang Y, Shen Q. Jiang Y, et al. Exp Ther Med. 2021 May;21(5):481. doi: 10.3892/etm.2021.9912. Epub 2021 Mar 12. Exp Ther Med. 2021. PMID: 33767776 Free PMC article.
• Connexin43 siRNA promotes HUVEC proliferation and inhibits apoptosis induced by ox-LDL: an involvement of ERK signaling pathway.
  Yin G, Yang X, Li B, Yang M, Ren M. Yin G, et al. Mol Cell Biochem. 2014 Sep;394(1-2):101-7. doi: 10.1007/s11010-014-2085-4. Epub 2014 May 16. Mol Cell Biochem. 2014. PMID: 24833468

References

1. 1. Kannel WB. New perspectives on cardiovascular risk factors. Am Heart J. 1987;114(1 Pt 2):213–219. - PubMed
2. 1. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ. 1994;308(6925):367–372. doi: 10.1136/bmj.308.6925.367. - DOI - PMC - PubMed
3. 1. Mitra S, Goyal T, Mehta JL. Oxidized LDL, LOX-1 and Atherosclerosis. Cardiovasc Drugs Ther. 2011;25(5):419–429. doi: 10.1007/s10557-011-6341-5. - DOI - PubMed
4. 1. Imazu M, Ono K, Tadehara F, Kajiwara K, Yamamoto H, Sumii K, Tasaki N, Oiwa J, Shimohara Y, Gomyo Y. et al.Plasma levels of oxidized low density lipoprotein are associated with stable angina pectoris and modalities of acute coronary syndrome. Int Heart J. 2008;49(5):515–524. doi: 10.1536/ihj.49.515. - DOI - PubMed
5. 1. Itabe H, Ueda M. Measurement of plasma oxidized low-density lipoprotein and its clinical implications. J Atheroscler Thromb. 2007;14(1):1–11. doi: 10.5551/jat.14.1. - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • BioMed Central
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information