Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins - PubMed (original) (raw)
Review
. 2013 Jan 20;163(2):87-96.
doi: 10.1016/j.jbiotec.2012.06.018. Epub 2012 Jun 28.
Affiliations
- PMID: 22750448
- DOI: 10.1016/j.jbiotec.2012.06.018
Review
Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins
Claudia Korneli et al. J Biotechnol. 2013.
Abstract
The high industrial relevance of the soil bacterium Bacillus megaterium as host for recombinant proteins is driving systems-wide analyses of its metabolic and regulatory networks. The present review highlights novel systems biology tools available to unravel the various cellular components on the level of metabolic and regulatory networks. These provide a rational platform for systems metabolic engineering of B. megaterium. In line, a number of interesting studies have particularly focused on studying recombinant B. megaterium in its industrial bioprocess environment thus integrating systems metabolic engineering with systems biotechnology and providing the full picture toward optimal processes.
Copyright © 2012 Elsevier B.V. All rights reserved.
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