Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal - PubMed (original) (raw)
Clinical Trial
. 2012 Nov-Dec;28(11-12):1115-21.
doi: 10.1016/j.nut.2012.02.010. Epub 2012 Jul 6.
Glenn R Gibson, Robin S Dickmann, Cyril W C Kendall, C-Y Oliver Chen, Adele Costabile, Elena M Comelli, Diane L McKay, Nelson G Almeida, David Jenkins, Gordon A Zello, Jeffrey B Blumberg
Affiliations
- PMID: 22771050
- DOI: 10.1016/j.nut.2012.02.010
Clinical Trial
Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal
Kevin C Maki et al. Nutrition. 2012 Nov-Dec.
Abstract
Objective: We assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.
Methods: This double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.
Results: The median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).
Conclusion: These results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
- Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children.
François IE, Lescroart O, Veraverbeke WS, Marzorati M, Possemiers S, Hamer H, Windey K, Welling GW, Delcour JA, Courtin CM, Verbeke K, Broekaert WF. François IE, et al. J Pediatr Gastroenterol Nutr. 2014 May;58(5):647-53. doi: 10.1097/MPG.0000000000000285. J Pediatr Gastroenterol Nutr. 2014. PMID: 24368315 Clinical Trial. - Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial.
François IE, Lescroart O, Veraverbeke WS, Marzorati M, Possemiers S, Evenepoel P, Hamer H, Houben E, Windey K, Welling GW, Delcour JA, Courtin CM, Verbeke K, Broekaert WF. François IE, et al. Br J Nutr. 2012 Dec 28;108(12):2229-42. doi: 10.1017/S0007114512000372. Epub 2012 Feb 28. Br J Nutr. 2012. PMID: 22370444 Clinical Trial. - Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study.
Cloetens L, Broekaert WF, Delaedt Y, Ollevier F, Courtin CM, Delcour JA, Rutgeerts P, Verbeke K. Cloetens L, et al. Br J Nutr. 2010 Mar;103(5):703-13. doi: 10.1017/S0007114509992248. Epub 2009 Dec 10. Br J Nutr. 2010. PMID: 20003568 Clinical Trial. - Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosaccharides, and xylooligosaccharides.
Broekaert WF, Courtin CM, Verbeke K, Van de Wiele T, Verstraete W, Delcour JA. Broekaert WF, et al. Crit Rev Food Sci Nutr. 2011 Feb;51(2):178-94. doi: 10.1080/10408390903044768. Crit Rev Food Sci Nutr. 2011. PMID: 21328111 Review. - Potential of wheat-based breakfast cereals as a source of dietary antioxidants.
Baublis AJ, Lu C, Clydesdale FM, Decker EA. Baublis AJ, et al. J Am Coll Nutr. 2000 Jun;19(3 Suppl):308S-311S. doi: 10.1080/07315724.2000.10718965. J Am Coll Nutr. 2000. PMID: 10875602 Review.
Cited by
- Functional and Nutritional Characteristics of Natural or Modified Wheat Bran Non-Starch Polysaccharides: A Literature Review.
Sztupecki W, Rhazi L, Depeint F, Aussenac T. Sztupecki W, et al. Foods. 2023 Jul 13;12(14):2693. doi: 10.3390/foods12142693. Foods. 2023. PMID: 37509785 Free PMC article. Review. - The Potential of Xylooligosaccharides as Prebiotics and Their Sustainable Production from Agro-Industrial by-Products.
Valladares-Diestra KK, de Souza Vandenberghe LP, Vieira S, Goyzueta-Mamani LD, de Mattos PBG, Manzoki MC, Soccol VT, Soccol CR. Valladares-Diestra KK, et al. Foods. 2023 Jul 12;12(14):2681. doi: 10.3390/foods12142681. Foods. 2023. PMID: 37509773 Free PMC article. Review. - Dietary Fiber Intake and Gut Microbiota in Human Health.
Fu J, Zheng Y, Gao Y, Xu W. Fu J, et al. Microorganisms. 2022 Dec 18;10(12):2507. doi: 10.3390/microorganisms10122507. Microorganisms. 2022. PMID: 36557760 Free PMC article. Review. - Integrated Technology for Cereal Bran Valorization: Perspectives for a Sustainable Industrial Approach.
Nemes SA, Călinoiu LF, Dulf FV, Fărcas AC, Vodnar DC. Nemes SA, et al. Antioxidants (Basel). 2022 Oct 31;11(11):2159. doi: 10.3390/antiox11112159. Antioxidants (Basel). 2022. PMID: 36358531 Free PMC article. Review. - Preparation and nutritional properties of xylooligosaccharide from agricultural and forestry byproducts: A comprehensive review.
Yan F, Tian S, Du K, Xue X, Gao P, Chen Z. Yan F, et al. Front Nutr. 2022 Sep 13;9:977548. doi: 10.3389/fnut.2022.977548. eCollection 2022. Front Nutr. 2022. PMID: 36176637 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical