The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research - PubMed (original) (raw)
Review
. 2012 Aug-Oct;147(2-3):227-47.
doi: 10.1016/j.jcpa.2012.05.010. Epub 2012 Jul 11.
Affiliations
- PMID: 22789861
- DOI: 10.1016/j.jcpa.2012.05.010
Free article
Review
The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research
J C Patterson-Kane et al. J Comp Pathol. 2012 Aug-Oct.
Free article
Abstract
The equine superficial digital flexor tendon (SDFT) is a frequently injured structure that is functionally and clinically equivalent to the human Achilles tendon (AT). Both act as critical energy-storage systems during high-speed locomotion and can accumulate exercise- and age-related microdamage that predisposes to rupture during normal activity. Significant advances in understanding of the biology and pathology of exercise-induced tendon injury have occurred through comparative studies of equine digital tendons with varying functions and injury susceptibilities. Due to the limitations of in-vivo work, determination of the mechanisms by which tendon cells contribute to and/or actively participate in the pathogenesis of microdamage requires detailed cell culture modelling. The phenotypes induced must ultimately be mapped back to the tendon tissue environment. The biology of tendon cells and their matrix, and the pathological changes occurring in the context of early injury in both horses and people are reviewed, with a particular focus on the use of various tendon cell and tissue culture systems to model these events.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
- The pathobiology of exercise-induced superficial digital flexor tendon injury in Thoroughbred racehorses.
Patterson-Kane JC, Firth EC. Patterson-Kane JC, et al. Vet J. 2009 Aug;181(2):79-89. doi: 10.1016/j.tvjl.2008.02.009. Epub 2008 Apr 10. Vet J. 2009. PMID: 18406184 - Achilles tendon injuries in elite athletes: lessons in pathophysiology from their equine counterparts.
Patterson-Kane JC, Rich T. Patterson-Kane JC, et al. ILAR J. 2014;55(1):86-99. doi: 10.1093/ilar/ilu004. ILAR J. 2014. PMID: 24936032 Review. - A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?
Thorpe CT, Clegg PD, Birch HL. Thorpe CT, et al. Equine Vet J. 2010 Mar;42(2):174-80. doi: 10.2746/042516409X480395. Equine Vet J. 2010. PMID: 20156256 Review. - Injuries of the calcaneal insertions of the superficial digital flexor tendon in 19 horses.
Wright IM, Minshall GJ. Wright IM, et al. Equine Vet J. 2012 Mar;44(2):136-42. doi: 10.1111/j.2042-3306.2011.00417.x. Epub 2011 Aug 18. Equine Vet J. 2012. PMID: 21848537 - Microdamage in the equine superficial digital flexor tendon.
O'Brien C, Marr N, Thorpe C. O'Brien C, et al. Equine Vet J. 2021 May;53(3):417-430. doi: 10.1111/evj.13331. Epub 2020 Sep 2. Equine Vet J. 2021. PMID: 32772396 Review.
Cited by
- Effects of minute oscillation stretching training on muscle and tendon stiffness and walking capability in people with type 2 diabetes.
Magris R, Monte A, Nardello F, Trinchi M, Vigolo N, Negri C, Moghetti P, Zamparo P. Magris R, et al. Eur J Appl Physiol. 2024 Sep 9. doi: 10.1007/s00421-024-05596-y. Online ahead of print. Eur J Appl Physiol. 2024. PMID: 39249539 - Immunology of Physical Exercise: Is Equus caballus an Appropriate Animal Model for Human Athletes?
Witkowska-Piłaszewicz O, Malin K, Dąbrowska I, Grzędzicka J, Ostaszewski P, Carter C. Witkowska-Piłaszewicz O, et al. Int J Mol Sci. 2024 May 10;25(10):5210. doi: 10.3390/ijms25105210. Int J Mol Sci. 2024. PMID: 38791248 Free PMC article. Review. - Treatment of Naturally Occurring Tendon Disease with Allogeneic Multipotent Mesenchymal Stromal Cells: A Randomized, Controlled, Triple-Blinded Pilot Study in Horses.
Burk J, Wittenberg-Voges L, Schubert S, Horstmeier C, Brehm W, Geburek F. Burk J, et al. Cells. 2023 Oct 24;12(21):2513. doi: 10.3390/cells12212513. Cells. 2023. PMID: 37947591 Free PMC article. Clinical Trial. - Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the "core" of the problem through a one health approach.
Schnabel LV, Koch DW. Schnabel LV, et al. J Am Vet Med Assoc. 2023 Aug 29;261(10):1435-1442. doi: 10.2460/javma.23.07.0388. Print 2023 Oct 1. J Am Vet Med Assoc. 2023. PMID: 37643722 Free PMC article. - Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).
Little D, Amadio PC, Awad HA, Cone SG, Dyment NA, Fisher MB, Huang AH, Koch DW, Kuntz AF, Madi R, McGilvray K, Schnabel LV, Shetye SS, Thomopoulos S, Zhao C, Soslowsky LJ. Little D, et al. J Orthop Res. 2023 Oct;41(10):2133-2162. doi: 10.1002/jor.25678. Epub 2023 Aug 28. J Orthop Res. 2023. PMID: 37573480 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical