The relationship between existence of typical symptoms and psychological factors in patients with erosive esophagitis - PubMed (original) (raw)

The relationship between existence of typical symptoms and psychological factors in patients with erosive esophagitis

Sang Pyo Lee et al. J Neurogastroenterol Motil. 2012 Jul.

Abstract

Background/aims: In Asian countries including Korea, the prevalence of gastroesophageal reflux disease (GERD) is on the rise and its clinical impact has been emphasized. The purpose of this study was to investigate the clinical characteristics of esophagitis patients with or without symptoms, and their association with psychological factors.

Methods: Subjects diagnosed as erosive esophagitis of Los Angeles-A or more in screening by upper gastrointestinal endoscopy were enrolled. Questionnaires regarding GERD symptoms and Symptom Checklist-90-Revision were used to identify the presence of psychological symptoms.

Results: There was no difference between the subjects' general characteristics (gender, age, body mass index, smoking and alcohol intake) according to the existence of typical symptoms in these patients with erosive esophagitis. Patients with typical GERD symptoms were more likely to have atypical symptoms, dyspepsia and higher scores on psychological symptoms (somatization, obsessive-compulsiveness and phobic anxiety) than those without.

Conclusions: Psychological symptoms and other gastrointestinal symptoms should be considered in the patients with erosive esophagitis.

Keywords: Eosphagitis; Gastroesophageal reflux; Psychological test.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Figure 1

Los Angeles (LA) classification in the symptomatic erosive esophagitis group, 13 (44.8%) were LA-A, 12 (41.4%) LA-B, 3 (10.3%) LA-C and 1 (3.4%) LA-D. In the asymptomatic erosive esophagitis group, 19 (73.1%) were LA-A, 7 (26.9%) LA-B, and none LA-C or LA-D.

Figure 2

Association with atypical symptoms. Twenty subjects (68.9%) in the symptomatic erosive esophagitis (SEE) group complained of globus, and 5 (19.2%) in the asymptomatic erosive esophagitis (AEE) group (P < 0.001). Fifteen (51.7%) complained of chronic cough in the SEE group, and 4 (15.3%) in the AEE group (P = 0.009).

Figure 3

Association with symptoms of functional dyspepsia. There were 11 (37.9%), 11 (37.9%) and 17 (58.6%) patients with epigastric pain, early satiation, and postprandial fullness, respectively, in the symptomatic erosive esophagitis group, and 1 (3.8%), 1 (3.8%) and 5 (19.2%), in the asymptomatic erosive esophagitis group. This difference was statistically significant (epigastric pain, P = 0.003; early satiation, P = 0.003; postprandial fullness, P = 0.005). SEE, symptomatic erosive esophagitis; AEE, asymptomatic erosive esophagitis.

Figure 4

Association with psychiatric symptoms. The mean values for somatization, obsessive-compulsive behavior and phobic anxiety were (symptomatic erosive esophagitis/asymptomatic erosive esophagitis) 52.37/44.62, 46.22/41.50 and 49.59/44.65, respectively. Somatization (P = 0.004), obsessive-compulsive behavior (P = 0.041) and phobic anxiety (P = 0.022) were statistically significant. SEE, symptomatic erosive esophagitis; AEE, asymptomatic erosive esophagitis; SCL-90-R, Symptom Checklist-90 Revision.

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References

1. 1. Fock KM, Talley NJ, Fass R, et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: update. J Gastroenterol Hepatol. 2008;23:8–22. - PubMed
2. 1. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–1920. - PubMed
3. 1. Locke GR, 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ., 3rd Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448–1456. - PubMed
4. 1. Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion. 1992;51(suppl 1):24–29. - PubMed
5. 1. Zagari RM, Fuccio L, Wallander MA, et al. Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study. Gut. 2008;57:1354–1359. - PubMed

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