The human microbiome: a hot spot of microbial horizontal gene transfer - PubMed (original) (raw)
. 2012 Nov;100(5):265-70.
doi: 10.1016/j.ygeno.2012.07.012. Epub 2012 Jul 25.
Affiliations
- PMID: 22841660
- DOI: 10.1016/j.ygeno.2012.07.012
Free article
The human microbiome: a hot spot of microbial horizontal gene transfer
Li Liu et al. Genomics. 2012 Nov.
Free article
Abstract
The human body harbors numerous microbes, and here exists a close relationship between microbes and human health. The Human Microbiome Project has generated whole genome sequences of several hundred human microbes. In this study, we identified horizontal gene transfer (HGT) events in human microbes and tried to elucidate the relationships between the gene-transferring microbes. A total of 13,514 high confidence HGT genes were identified in 308 human microbes. The horizontally transferred genes were enriched for Gene Ontology terms pertaining to catalytic functions and metabolic processes. Construction of an HGT event network suggested that the human microbes could be divided into specific communities which only partly overlap their distribution in human body. Our research suggests that human microbiome may facilitate frequent horizontal gene transfer among bacteria in human body. Awareness of HGT in human microbiome may aid our understanding of the relationship between the human microbiome and human health.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
- Horizontal gene transfer in an acid mine drainage microbial community.
Guo J, Wang Q, Wang X, Wang F, Yao J, Zhu H. Guo J, et al. BMC Genomics. 2015 Jul 4;16(1):496. doi: 10.1186/s12864-015-1720-0. BMC Genomics. 2015. PMID: 26141154 Free PMC article. - Ecology drives a global network of gene exchange connecting the human microbiome.
Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ. Smillie CS, et al. Nature. 2011 Oct 30;480(7376):241-4. doi: 10.1038/nature10571. Nature. 2011. PMID: 22037308 - Human microbiome: a genetic bazaar for microbes?
Langille MG, Meehan CJ, Beiko RG. Langille MG, et al. Curr Biol. 2012 Jan 10;22(1):R20-2. doi: 10.1016/j.cub.2011.11.023. Curr Biol. 2012. PMID: 22240474 Review. - Horizontal gene transfer in fungi.
Fitzpatrick DA. Fitzpatrick DA. FEMS Microbiol Lett. 2012 Apr;329(1):1-8. doi: 10.1111/j.1574-6968.2011.02465.x. Epub 2011 Dec 15. FEMS Microbiol Lett. 2012. PMID: 22112233 Review.
Cited by
- The soil in our microbial DNA informs about environmental interfaces across host and subsistence modalities.
Schnorr SL. Schnorr SL. Philos Trans R Soc Lond B Biol Sci. 2020 Nov 23;375(1812):20190577. doi: 10.1098/rstb.2019.0577. Epub 2020 Oct 5. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 33012224 Free PMC article. - Host-microbe interactions in microgravity: assessment and implications.
Foster JS, Wheeler RM, Pamphile R. Foster JS, et al. Life (Basel). 2014 May 26;4(2):250-66. doi: 10.3390/life4020250. Life (Basel). 2014. PMID: 25370197 Free PMC article. Review. - Disrupted human-pathogen co-evolution: a model for disease.
Kodaman N, Sobota RS, Mera R, Schneider BG, Williams SM. Kodaman N, et al. Front Genet. 2014 Aug 25;5:290. doi: 10.3389/fgene.2014.00290. eCollection 2014. Front Genet. 2014. PMID: 25202324 Free PMC article. - Genetic and phenotypic assessments for the safety of probiotic Bacillus clausii 088AE.
Saroj DB, Ahire JJ, Shukla R. Saroj DB, et al. 3 Biotech. 2023 Jul;13(7):238. doi: 10.1007/s13205-023-03662-4. Epub 2023 Jun 16. 3 Biotech. 2023. PMID: 37333714 Free PMC article. - Potential Effects of Horizontal Gene Exchange in the Human Gut.
Lerner A, Matthias T, Aminov R. Lerner A, et al. Front Immunol. 2017 Nov 27;8:1630. doi: 10.3389/fimmu.2017.01630. eCollection 2017. Front Immunol. 2017. PMID: 29230215 Free PMC article.