Microbial translocation in HIV infection: causes, consequences and treatment opportunities - PubMed (original) (raw)
Review
doi: 10.1038/nrmicro2848. Epub 2012 Aug 13.
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- PMID: 22886237
- DOI: 10.1038/nrmicro2848
Review
Microbial translocation in HIV infection: causes, consequences and treatment opportunities
Netanya G Sandler et al. Nat Rev Microbiol. 2012 Sep.
Abstract
Systemic immune activation is increased in HIV-infected individuals, even in the setting of virus suppression with antiretroviral therapy. Although numerous factors may contribute, microbial products have recently emerged as potential drivers of this immune activation. In this Review, we describe the intestinal damage that occurs in HIV infection, the evidence for translocation of microbial products into the systemic circulation and the pathways by which these products activate the immune system. We also discuss novel therapies that disrupt the translocation of microbial products and the downstream effects of microbial translocation.
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