Effect of intervention in subjects with high risk of diabetes mellitus in pakistan - PubMed (original) (raw)

Effect of intervention in subjects with high risk of diabetes mellitus in pakistan

Muhammad Zafar Iqbal Hydrie et al. J Nutr Metab. 2012.

Erratum in

• Corrigendum to "Effect of Intervention in Subjects with High Risk of Diabetes Mellitus in Pakistan".
  Hydrie MZ, Basit A, Shera AS, Hussain A. Hydrie MZ, et al. J Nutr Metab. 2015;2015:289294. doi: 10.1155/2015/289294. Epub 2015 Oct 27. J Nutr Metab. 2015. PMID: 26600947 Free PMC article.

Abstract

Aims. To observe the rate of conversion from impaired glucose tolerance (IGT) to diabetes following lifestyle modification (LSM) or a combination of lifestyle and metformin compared to a control population with 18-month followup. Methods. Forty screening camps were organized, which 5000 people attended. Around 2300 persons filled the questionnaire and 1825 subjects were identified as high risk. Of 1739 subjects who took the oral glucose tolerance test, 317 subjects were identified as IGT. The 317 IGT subjects were randomized into three groups: control group was given standard medical advice, LSM group was given intensive lifestyle modification advice, while LSM + drug group was given intensive lifestyle advice and metformin 500 mg twice daily. Results. At the end, 273 subjects completed the study, giving a compliance rate of 86%. Total of 47 incident cases of diabetes were diagnosed (overall incidence was 4 cases per 1000 person-months with the incidence of 8.6 cases in control group, 2.5 cases in the LSM, and 2.3 cases in the LSM + drug groups). Conclusions. Study showed that lifestyle intervention had a major impact in preventing diabetes among IGT subjects in this region. Adding drug did not show any improved results. We recommend lifestyle advice and followup should be incorporated in primary health care.

PubMed Disclaimer

Figures

Figure 1

Flowchart with recruitment of persons for the oral glucose tolerance test (OGTT), screening, and randomization.

Figure 2

Weight changes in 18 months. (Significant difference between the Control and LSM + drug groups: P value = 0.003).

Figure 3

Waist circumference. (No significant difference seen between the three groups).

Similar articles

• The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1).
  Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V; Indian Diabetes Prevention Programme (IDPP). Ramachandran A, et al. Diabetologia. 2006 Feb;49(2):289-97. doi: 10.1007/s00125-005-0097-z. Epub 2006 Jan 4. Diabetologia. 2006. PMID: 16391903 Clinical Trial.
• A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial.
  Wijesuriya M, Fountoulakis N, Guess N, Banneheka S, Vasantharajah L, Gulliford M, Viberti G, Gnudi L, Karalliedde J. Wijesuriya M, et al. BMC Med. 2017 Aug 30;15(1):146. doi: 10.1186/s12916-017-0905-6. BMC Med. 2017. PMID: 28851373 Free PMC article. Clinical Trial.
• Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention.
  Unwin N, Shaw J, Zimmet P, Alberti KG. Unwin N, et al. Diabet Med. 2002 Sep;19(9):708-23. doi: 10.1046/j.1464-5491.2002.00835.x. Diabet Med. 2002. PMID: 12207806 Review.

Cited by

• Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention.
  Hostalek U, Gwilt M, Hildemann S. Hostalek U, et al. Drugs. 2015 Jul;75(10):1071-94. doi: 10.1007/s40265-015-0416-8. Drugs. 2015. PMID: 26059289 Free PMC article. Review.
• Lifestyle interventions in preventing new type 2 diabetes in Asian populations.
  Modesti PA, Galanti G, Cala' P, Calabrese M. Modesti PA, et al. Intern Emerg Med. 2016 Apr;11(3):375-84. doi: 10.1007/s11739-015-1325-2. Epub 2015 Oct 16. Intern Emerg Med. 2016. PMID: 26475162 Review.
• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
  Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B. Madsen KS, et al. Cochrane Database Syst Rev. 2019 Dec 3;12(12):CD008558. doi: 10.1002/14651858.CD008558.pub2. Cochrane Database Syst Rev. 2019. PMID: 31794067 Free PMC article.
• The Effectiveness of Metformin in Diabetes Prevention: A Systematic Review and Meta-Analysis.
  Patel D, Ayesha IE, Monson NR, Klair N, Patel U, Saxena A, Hamid P. Patel D, et al. Cureus. 2023 Sep 28;15(9):e46108. doi: 10.7759/cureus.46108. eCollection 2023 Sep. Cureus. 2023. PMID: 37900422 Free PMC article. Review.
• Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among Persons at Increased Risk: A Systematic Review for the Community Preventive Services Task Force.
  Balk EM, Earley A, Raman G, Avendano EA, Pittas AG, Remington PL. Balk EM, et al. Ann Intern Med. 2015 Sep 15;163(6):437-51. doi: 10.7326/M15-0452. Ann Intern Med. 2015. PMID: 26167912 Free PMC article. Review.

References

1. 1. International Diabetes Federation. The Diabetes Atlas, e-Atlas. 2011.
2. 1. Alberti KGMM, Zimmet P, Shaw J. International diabetes federation: a consensus on type 2 diabetes prevention. Diabetic Medicine. 2007;24(5):451–463. - PubMed
3. 1. Hussain A, Claussen B, Ramachandran A, Williams R. Prevention of type 2 diabetes: a review. Diabetes Research and Clinical Practice. 2007;76(3):317–326. - PubMed
4. 1. Marrero DG. The prevention of type 2 diabetes: an overview. Journal of Diabetes Science and Technology. 2009;3(4):756–760. - PMC - PubMed
5. 1. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and diabetes study. Diabetes Care. 1997;20(4):537–544. - PubMed

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Hindawi Limited
  • PubMed Central