Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population - PubMed (original) (raw)

Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population

Karthick Rajendran et al. Thromb J. 2012.

Abstract

Background: Obesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. There is an upregulation of inflammatory markers such as interleukin-6, interleukin-6 receptor and acute phase protein CRP in Acute Myocardial Infarction (AMI) patients but the exact mechanism linking obesity and inflammation is not known. It is of our interest to investigate if serum leptin (ob gene product) is associated with AMI and correlated with inflammatory proteins namely Interleukin-6 (IL-6) and high sensitivity - C reactive protein (hs-CRP).

Results: Serum leptin levels were significantly higher in AMI patients when compared to Non-CVD controls. IL-6 and hs-CRP were also elevated in the AMI group and leptin correlated positively with IL-6 and hs-CRP. Incidentally this is the first report from Chennai based population, India.

Conclusions: The strong correlation between serum levels of leptin and IL-6 implicates an involvement of leptin in the upregulation of inflammatory cytokines during AMI. We hypothesise that the increase in values of IL-6, hs-CRP and their correlation to leptin in AMI patients could be due to participation of leptin in the signaling cascade after myocardial ischemia.

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Figures

Figure 1

Figure 1

Correlation between serum levels of leptin (ng/ml), IL-6 (pg/ml) and hs-CRP (mg/L) in patients with AMI (Linear regression analysis). A. Correlation between serum leptin (ng/ml) and IL-6 (pg/ml) in patients with acute myocardial infarction. Significant positive correlation is found (R2 = 0. 742). B. Correlation between serum leptin (ng/ml) and hs-CRP (mg/L) in patients with acute myocardial infarction. Positive correlation is found (R2 = 0.059).

Figure 2

Figure 2

Correlation between serum levels of leptin (ng/ml), IL-6 (pg/ml) and hs-CRP (mg/L) in control subjects (Linear regression analysis). A. Correlation between serum leptin (ng/ml) and IL-6 (pg/ml) in control subjects. No significant correlation is found (R2 = 0.154). B. Correlation between serum leptin (ng/ml) and hs-CRP (mg/L) in control subjects. No significant correlation is found (R2 = 0.002).

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