Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women - PubMed (original) (raw)
doi: 10.3945/ajcn.112.042036. Epub 2012 Aug 22.
Affiliations
- PMID: 22914551
- DOI: 10.3945/ajcn.112.042036
Free article
Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women
Amy Jennings et al. Am J Clin Nutr. 2012 Oct.
Free article
Abstract
Background: Although a high intake of some flavonoid subclasses may reduce cardiovascular disease mortality, data regarding the in vivo mechanisms of action are limited.
Objective: We examined associations between habitual flavonoid intakes and direct measures of arterial stiffness, central blood pressure, and atherosclerosis.
Design: In a cross-sectional study of 1898 women aged 18-75 y from the TwinsUK registry, intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from validated food-frequency questionnaires by using an updated and extended USDA database. Direct measures of arterial stiffness and atherosclerosis included central systolic blood pressure (cSBP), central diastolic blood pressure, mean arterial pressure (MAP), augmentation index, pulse wave velocity (PWV), and intima-media thickness.
Results: In multivariate analyses, a higher anthocyanin intake was associated with significantly lower cSBP (mean ± SE: -3.0 ± 1.4 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.02), MAP (-2.3 ± 1.2 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.04), and PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04), whereas a higher flavone intake was associated with a lower PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04). Although a higher wine and berry intake was associated with a lower PWV, no associations were observed for total and other flavonoid subclasses.
Conclusions: These data, which include direct measures of arterial stiffness and thickness, suggest that higher intake of anthocyanins and flavones are inversely associated with lower arterial stiffness. The intakes of anthocyanins associated with these findings could be incorporated into the diet by the consumption of 1-2 portions of berries daily and are, therefore, relevant for public health strategies to reduce cardiovascular disease risk.
Similar articles
- Amino Acid Intakes Are Inversely Associated with Arterial Stiffness and Central Blood Pressure in Women.
Jennings A, MacGregor A, Welch A, Chowienczyk P, Spector T, Cassidy A. Jennings A, et al. J Nutr. 2015 Sep;145(9):2130-8. doi: 10.3945/jn.115.214700. Epub 2015 Jul 22. J Nutr. 2015. PMID: 26203100 Free PMC article. - Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins.
Jennings A, MacGregor A, Spector T, Cassidy A. Jennings A, et al. Am J Clin Nutr. 2017 Mar;105(3):626-634. doi: 10.3945/ajcn.116.144394. Epub 2017 Jan 18. Am J Clin Nutr. 2017. PMID: 28100511 Free PMC article. - Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults.
Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF. Cassidy A, et al. Am J Clin Nutr. 2015 Jul;102(1):172-81. doi: 10.3945/ajcn.115.108555. Epub 2015 May 27. Am J Clin Nutr. 2015. PMID: 26016863 Free PMC article. - Flavonoids and arterial stiffness: promising perspectives.
Lilamand M, Kelaiditi E, Guyonnet S, Antonelli Incalzi R, Raynaud-Simon A, Vellas B, Cesari M. Lilamand M, et al. Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):698-704. doi: 10.1016/j.numecd.2014.01.015. Epub 2014 Jan 31. Nutr Metab Cardiovasc Dis. 2014. PMID: 24656854 Review. - An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk.
Parmenter BH, Croft KD, Hodgson JM, Dalgaard F, Bondonno CP, Lewis JR, Cassidy A, Scalbert A, Bondonno NP. Parmenter BH, et al. Food Funct. 2020 Aug 19;11(8):6777-6806. doi: 10.1039/d0fo01118e. Food Funct. 2020. PMID: 32725042 Review.
Cited by
- Dietary Intake of Polyphenols and All-Cause Mortality: A Systematic Review with Meta-Analysis.
Zupo R, Castellana F, Lisco G, Corbo F, Crupi P, Sardone R, Panza F, Lozupone M, Rondanelli M, Clodoveo ML. Zupo R, et al. Metabolites. 2024 Jul 25;14(8):404. doi: 10.3390/metabo14080404. Metabolites. 2024. PMID: 39195500 Free PMC article. Review. - Grape/Blueberry Anthocyanins and Their Gut-Derived Metabolites Attenuate LPS/Nigericin-Induced Inflammasome Activation by Inhibiting ASC Speck Formation in THP-1 Monocytes.
Behrendt I, Röder I, Will F, Michel G, Friedrich E, Grote D, Martin Z, Dötzer HP, Fasshauer M, Speckmann M, Kuntz S. Behrendt I, et al. Metabolites. 2024 Apr 3;14(4):203. doi: 10.3390/metabo14040203. Metabolites. 2024. PMID: 38668331 Free PMC article. - Dietary polyphenol intake, body composition and components of metabolic syndrome in a sample overweight and obese adults: a cross-sectional study.
Alshahrani SH, Al-Attar Z, Daabo HMA, Alshahrani NZ, Al-Shawi SG, Núñez EFD, Hussien BM, Hjazi A, Hassan ZF. Alshahrani SH, et al. BMC Endocr Disord. 2023 Nov 27;23(1):261. doi: 10.1186/s12902-023-01507-y. BMC Endocr Disord. 2023. PMID: 38012598 Free PMC article. - Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review.
Gál R, Halmosi R, Gallyas F Jr, Tschida M, Mutirangura P, Tóth K, Alexy T, Czopf L. Gál R, et al. Biomedicines. 2023 Oct 25;11(11):2888. doi: 10.3390/biomedicines11112888. Biomedicines. 2023. PMID: 38001889 Free PMC article. Review. - The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study.
Charoenwoodhipong P, Holt RR, Keen CL, Hedayati N, Sato T, Sone T, Hackman RM. Charoenwoodhipong P, et al. Nutrients. 2023 Sep 19;15(18):4054. doi: 10.3390/nu15184054. Nutrients. 2023. PMID: 37764837 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous