DExD/H-box RNA helicases in ribosome biogenesis - PubMed (original) (raw)
Review
DExD/H-box RNA helicases in ribosome biogenesis
Roman Martin et al. RNA Biol. 2013 Jan.
Abstract
Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while eukaryotes strictly require multiple DExD/H-box proteins that are involved in the much more complex ribosome biogenesis pathway. Here, RNA helicases are thought to act in structural remodeling of the RNPs including the modulation of protein binding, and they are required for allowing access or the release of specific snoRNPs from pre-ribosomes. Interestingly, helicase action is modulated by specific cofactors that can regulate recruitment and enzymatic activity. This review summarizes the current knowledge and focuses on recent findings and open questions on RNA helicase function and regulation in ribosome synthesis.
Keywords: ATPase; RNA unwinding; RNP; snoRNA; translation.
Figures
Figure 1. Processing of rRNA in bacteria. The schematic representation shows the rRNA processing pathway in Escherichia coli. Cleavage sites and the corresponding nucleases are indicated. Adapted from ref. .
Figure 2. Processing of rRNA in Saccharomyces cerevisiae. The schematic representation shows the rRNA processing pathway in yeast. The direction of transcription is indicated for a rDNA repeat by horizontal arrows and processing sites are marked by small vertical arrows. The nuclear envelope is represented by horizontal bars, and nucleus (Nu) and cytoplasm (Cy) are indicated.
Figure 3. Processing of rRNA in human cells. The schematic representation shows the rRNA processing pathway in human cells. Processing sites are marked by vertical arrows. The nuclear envelope is represented by horizontal bars, and nucleus (Nu) and cytoplasm (Cy) are indicated. Modified from ref. .
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