Bending membranes - PubMed (original) (raw)

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doi: 10.1038/ncb2570.

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• PMID: 22945258
• DOI: 10.1038/ncb2570

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Bending membranes

Tom Kirchhausen. Nat Cell Biol. 2012 Sep.

Abstract

It is widely assumed that peripheral membrane proteins induce intracellular membrane curvature by the asymmetric insertion of a protein segment into the lipid bilayer, or by imposing shape by adhesion of a curved protein domain to the membrane surface. Two papers now provide convincing evidence challenging these views. The first shows that specific assembly of a clathrin protein scaffold, coupled to the membrane, seems to be the most prevalent mechanism for bending a lipid bilayer in a cell. The second reports that membrane crowding, driven by protein-protein interactions, can also drive membrane bending, even in the absence of any protein insertion into the bilayer.

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• Membrane bending by protein-protein crowding.
  Stachowiak JC, Schmid EM, Ryan CJ, Ann HS, Sasaki DY, Sherman MB, Geissler PL, Fletcher DA, Hayden CC. Stachowiak JC, et al. Nat Cell Biol. 2012 Sep;14(9):944-9. doi: 10.1038/ncb2561. Epub 2012 Aug 19. Nat Cell Biol. 2012. PMID: 22902598

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