Revising the human mutation rate: implications for understanding human evolution - PubMed (original) (raw)
Review
. 2012 Oct;13(10):745-53.
doi: 10.1038/nrg3295. Epub 2012 Sep 11.
Affiliations
- PMID: 22965354
- DOI: 10.1038/nrg3295
Review
Revising the human mutation rate: implications for understanding human evolution
Aylwyn Scally et al. Nat Rev Genet. 2012 Oct.
Erratum in
- Nat Rev Genet. 2012 Nov;13(11):824
Abstract
It is now possible to make direct measurements of the mutation rate in modern humans using next-generation sequencing. These measurements reveal a value that is approximately half of that previously derived from fossil calibration, and this has implications for our understanding of demographic events in human evolution and other aspects of population genetics. Here, we discuss the implications of a lower-than-expected mutation rate in relation to the timescale of human evolution.
Similar articles
- Studies slow the human DNA clock.
Callaway E. Callaway E. Nature. 2012 Sep 20;489(7416):343-4. doi: 10.1038/489343a. Nature. 2012. PMID: 22996522 No abstract available. - Archaic mitochondrial DNA inserts in modern day nuclear genomes.
Bücking R, Cox MP, Hudjashov G, Saag L, Sudoyo H, Stoneking M. Bücking R, et al. BMC Genomics. 2019 Dec 26;20(1):1017. doi: 10.1186/s12864-019-6392-8. BMC Genomics. 2019. PMID: 31878873 Free PMC article. - Using genetic evidence to evaluate four palaeoanthropological hypotheses for the timing of Neanderthal and modern human origins.
Endicott P, Ho SY, Stringer C. Endicott P, et al. J Hum Evol. 2010 Jul;59(1):87-95. doi: 10.1016/j.jhevol.2010.04.005. Epub 2010 May 26. J Hum Evol. 2010. PMID: 20510437 - Archaic human genomics.
Disotell TR. Disotell TR. Am J Phys Anthropol. 2012;149 Suppl 55:24-39. doi: 10.1002/ajpa.22159. Epub 2012 Nov 2. Am J Phys Anthropol. 2012. PMID: 23124308 Review. - No evidence of a Neanderthal contribution to modern human diversity.
Hodgson JA, Disotell TR. Hodgson JA, et al. Genome Biol. 2008;9(2):206. doi: 10.1186/gb-2008-9-2-206. Epub 2008 Feb 18. Genome Biol. 2008. PMID: 18304371 Free PMC article. Review.
Cited by
- Evidence for recent, population-specific evolution of the human mutation rate.
Harris K. Harris K. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3439-44. doi: 10.1073/pnas.1418652112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733855 Free PMC article. - A comparison of Y-chromosomal lineage dating using either resequencing or Y-SNP plus Y-STR genotyping.
Wei W, Ayub Q, Xue Y, Tyler-Smith C. Wei W, et al. Forensic Sci Int Genet. 2013 Dec;7(6):568-572. doi: 10.1016/j.fsigen.2013.03.014. Epub 2013 Jun 13. Forensic Sci Int Genet. 2013. PMID: 23768990 Free PMC article. - Recent advances in the study of fine-scale population structure in humans.
Novembre J, Peter BM. Novembre J, et al. Curr Opin Genet Dev. 2016 Dec;41:98-105. doi: 10.1016/j.gde.2016.08.007. Epub 2016 Sep 20. Curr Opin Genet Dev. 2016. PMID: 27662060 Free PMC article. Review. - Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route.
Fregel R, Cabrera V, Larruga JM, Abu-Amero KK, González AM. Fregel R, et al. PLoS One. 2015 Jun 8;10(6):e0129839. doi: 10.1371/journal.pone.0129839. eCollection 2015. PLoS One. 2015. PMID: 26053380 Free PMC article. - _Homo neanderthalensi_s and the evolutionary origins of ritual in Homo sapiens.
Nielsen M, Langley MC, Shipton C, Kapitány R. Nielsen M, et al. Philos Trans R Soc Lond B Biol Sci. 2020 Aug 17;375(1805):20190424. doi: 10.1098/rstb.2019.0424. Epub 2020 Jul 29. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 32594872 Free PMC article.
References
- Evolution. 2009 Oct;63(10):2547-62 - PubMed
- Science. 2012 Jul 6;337(6090):100-4 - PubMed
- Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11231-6 - PubMed
- J Hum Evol. 2009 Mar;56(3):219-46 - PubMed
- PLoS One. 2011;6(11):e28239 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources