Revising the human mutation rate: implications for understanding human evolution - PubMed (original) (raw)
Review
. 2012 Oct;13(10):745-53.
doi: 10.1038/nrg3295. Epub 2012 Sep 11.
Affiliations
- PMID: 22965354
- DOI: 10.1038/nrg3295
Review
Revising the human mutation rate: implications for understanding human evolution
Aylwyn Scally et al. Nat Rev Genet. 2012 Oct.
Erratum in
- Nat Rev Genet. 2012 Nov;13(11):824
Abstract
It is now possible to make direct measurements of the mutation rate in modern humans using next-generation sequencing. These measurements reveal a value that is approximately half of that previously derived from fossil calibration, and this has implications for our understanding of demographic events in human evolution and other aspects of population genetics. Here, we discuss the implications of a lower-than-expected mutation rate in relation to the timescale of human evolution.
Similar articles
- Studies slow the human DNA clock.
Callaway E. Callaway E. Nature. 2012 Sep 20;489(7416):343-4. doi: 10.1038/489343a. Nature. 2012. PMID: 22996522 No abstract available. - Archaic mitochondrial DNA inserts in modern day nuclear genomes.
Bücking R, Cox MP, Hudjashov G, Saag L, Sudoyo H, Stoneking M. Bücking R, et al. BMC Genomics. 2019 Dec 26;20(1):1017. doi: 10.1186/s12864-019-6392-8. BMC Genomics. 2019. PMID: 31878873 Free PMC article. - Using genetic evidence to evaluate four palaeoanthropological hypotheses for the timing of Neanderthal and modern human origins.
Endicott P, Ho SY, Stringer C. Endicott P, et al. J Hum Evol. 2010 Jul;59(1):87-95. doi: 10.1016/j.jhevol.2010.04.005. Epub 2010 May 26. J Hum Evol. 2010. PMID: 20510437 - Archaic human genomics.
Disotell TR. Disotell TR. Am J Phys Anthropol. 2012;149 Suppl 55:24-39. doi: 10.1002/ajpa.22159. Epub 2012 Nov 2. Am J Phys Anthropol. 2012. PMID: 23124308 Review. - No evidence of a Neanderthal contribution to modern human diversity.
Hodgson JA, Disotell TR. Hodgson JA, et al. Genome Biol. 2008;9(2):206. doi: 10.1186/gb-2008-9-2-206. Epub 2008 Feb 18. Genome Biol. 2008. PMID: 18304371 Free PMC article. Review.
Cited by
- Characterization and distribution of de novo mutations in the zebra finch.
Liang X, Yang S, Wang D, Knief U. Liang X, et al. Commun Biol. 2024 Oct 2;7(1):1243. doi: 10.1038/s42003-024-06945-5. Commun Biol. 2024. PMID: 39358581 Free PMC article. - Inference and applications of ancestral recombination graphs.
Nielsen R, Vaughn AH, Deng Y. Nielsen R, et al. Nat Rev Genet. 2024 Sep 30. doi: 10.1038/s41576-024-00772-4. Online ahead of print. Nat Rev Genet. 2024. PMID: 39349760 Review. - Demographic History and Inbreeding in Two Declining Sea Duck Species Inferred From Whole-Genome Sequence Data.
Cádiz MI, Tengstedt ANB, Sørensen IH, Pedersen ES, Fox AD, Hansen MM. Cádiz MI, et al. Evol Appl. 2024 Sep 10;17(9):e70008. doi: 10.1111/eva.70008. eCollection 2024 Sep. Evol Appl. 2024. PMID: 39257569 Free PMC article. - Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks.
Pankratov V, Mezzavilla M, Aneli S, Kuznetsov IA, Fusco D, Wilson JF, Metspalu M, Provero P, Pagani L, Marnetto D. Pankratov V, et al. Eur J Hum Genet. 2024 Aug 10. doi: 10.1038/s41431-024-01678-9. Online ahead of print. Eur J Hum Genet. 2024. PMID: 39127804 - Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong-Mien speakers.
Gao Y, Zhang X, Chen H, Lu Y, Ma S, Yang Y, Zhang M, Xu S. Gao Y, et al. BMC Biol. 2024 Mar 13;22(1):59. doi: 10.1186/s12915-024-01838-9. BMC Biol. 2024. PMID: 38475771 Free PMC article.
References
- Evolution. 2009 Oct;63(10):2547-62 - PubMed
- Science. 2012 Jul 6;337(6090):100-4 - PubMed
- Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11231-6 - PubMed
- J Hum Evol. 2009 Mar;56(3):219-46 - PubMed
- PLoS One. 2011;6(11):e28239 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources