Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison - PubMed (original) (raw)

Comparative Study

. 2013 Feb;225(4):781-90.

doi: 10.1007/s00213-012-2865-z. Epub 2012 Sep 16.

Affiliations

• PMID: 22983145
• DOI: 10.1007/s00213-012-2865-z

Comparative Study

Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison

Justine Renard et al. Psychopharmacology (Berl). 2013 Feb.

Abstract

Rationale: During cerebral development, adolescence is a critical phase in which the endocannabinoid system plays an important role in regulating various neurotransmitters. Moreover, evidence from both human and animal studies suggests that chronic cannabinoid exposure during this vulnerable period can induce persistent brain and behavioural alterations.

Objectives: The aim of this study was to compare the long-term cognitive consequences of chronic adolescence cannabinoid exposure between Lister Hooded rats and Wistar rats.

Methods: Rats of both strains were injected daily throughout their adolescent or adult periods with vehicle or with incremental doses of the synthetic cannabinoid CB1 receptor agonist CP55,940 (CP). Short-term and spatial working memories were assessed using the object recognition and object location, tasks respectively. For both tasks, the effect of a 30- or 120-min delay between the learning and the testing phase was investigated.

Results: In the object recognition task, adolescent CP exposure impaired short-term memory after both delays in both strains. In contrast, in the object location task, adolescent CP exposure impaired spatial working memory in the Wistar rats after a 30-min delay, whereas the Lister Hooded rats exhibited a similar effect only after a 120-min delay. In these tests, no long-term deleterious effects were found following adult CP exposure in either strain.

Conclusions: Our results confirm that adolescence is a critical period for the deleterious effects of cannabinoids on cognition and that these deleterious effects on spatial working memory are more strain-dependent than the effects observed on short-term memory.

PubMed Disclaimer

Similar articles

• Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats.
  O'Shea M, McGregor IS, Mallet PE. O'Shea M, et al. J Psychopharmacol. 2006 Sep;20(5):611-21. doi: 10.1177/0269881106065188. Epub 2006 May 19. J Psychopharmacol. 2006. PMID: 16714325
• Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats.
  O'Shea M, Singh ME, McGregor IS, Mallet PE. O'Shea M, et al. J Psychopharmacol. 2004 Dec;18(4):502-8. doi: 10.1177/026988110401800407. J Psychopharmacol. 2004. PMID: 15582916
• Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex.
  Renard J, Vitalis T, Rame M, Krebs MO, Lenkei Z, Le Pen G, Jay TM. Renard J, et al. Eur Neuropsychopharmacol. 2016 Jan;26(1):55-64. doi: 10.1016/j.euroneuro.2015.11.005. Epub 2015 Dec 3. Eur Neuropsychopharmacol. 2016. PMID: 26689328
• Exposure to cannabinoids can lead to persistent cognitive and psychiatric disorders.
  Krebs MO, Kebir O, Jay TM. Krebs MO, et al. Eur J Pain. 2019 Aug;23(7):1225-1233. doi: 10.1002/ejp.1377. Epub 2019 Mar 19. Eur J Pain. 2019. PMID: 30793421 Review.
• The influence of cannabinoids on learning and memory processes of the dorsal striatum.
  Goodman J, Packard MG. Goodman J, et al. Neurobiol Learn Mem. 2015 Nov;125:1-14. doi: 10.1016/j.nlm.2015.06.008. Epub 2015 Jun 17. Neurobiol Learn Mem. 2015. PMID: 26092091 Review.

Cited by

• Prevalence of Marijuana Use Disorders in the United States Between 2001-2002 and 2012-2013.
  Hasin DS, Saha TD, Kerridge BT, Goldstein RB, Chou SP, Zhang H, Jung J, Pickering RP, Ruan WJ, Smith SM, Huang B, Grant BF. Hasin DS, et al. JAMA Psychiatry. 2015 Dec;72(12):1235-42. doi: 10.1001/jamapsychiatry.2015.1858. JAMA Psychiatry. 2015. PMID: 26502112 Free PMC article.
• Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains.
  Leishman E, Murphy MN, Murphy MI, Mackie K, Bradshaw HB. Leishman E, et al. Front Mol Neurosci. 2018 Nov 27;11:436. doi: 10.3389/fnmol.2018.00436. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30542263 Free PMC article.
• Medical marijuana laws and adolescent marijuana use in the USA from 1991 to 2014: results from annual, repeated cross-sectional surveys.
  Hasin DS, Wall M, Keyes KM, Cerdá M, Schulenberg J, O'Malley PM, Galea S, Pacula R, Feng T. Hasin DS, et al. Lancet Psychiatry. 2015 Jul;2(7):601-8. doi: 10.1016/S2215-0366(15)00217-5. Epub 2015 Jun 15. Lancet Psychiatry. 2015. PMID: 26303557 Free PMC article.
• URB597 induces subtle changes to aggression in adult Lister Hooded rats.
  Warren WG, Hale E, Papagianni EP, Cassaday HJ, Stevenson CW, Stubbendorff C. Warren WG, et al. Front Psychiatry. 2022 Aug 12;13:885146. doi: 10.3389/fpsyt.2022.885146. eCollection 2022. Front Psychiatry. 2022. PMID: 36032247 Free PMC article.

References

1. 1. Psychopharmacology (Berl). 1982;77(2):117-23 - PubMed
2. 1. Neurotoxicol Teratol. 2010 Sep-Oct;32(5):515-24 - PubMed
3. 1. Neurosci Biobehav Rev. 2000 Jun;24(4):417-63 - PubMed
4. 1. Am J Dis Child. 1989 Oct;143(10):1214-9 - PubMed
5. 1. Behav Neurosci. 2010 Dec;124(6):789-99 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Miscellaneous

  • NCI CPTAC Assay Portal