Cells of origin of the spinohypothalamic tract in the rat - PubMed (original) (raw)

. 1990 Jan 15;291(3):329-44.

doi: 10.1002/cne.902910302.

Affiliations

• PMID: 2298937
• DOI: 10.1002/cne.902910302

Cells of origin of the spinohypothalamic tract in the rat

R Burstein et al. J Comp Neurol. 1990.

Abstract

We recently demonstrated that large numbers of neurons in the spinal cord of rats project directly to the hypothalamus. In the present study, we used the retrograde tracer Fluoro-Gold (FG) to examine this projection more completely. In the first series of studies, we attempted to label the entire population of spinal cord neurons that project to the hypothalamus. Injections that virtually filled the hypothalamus on one side without spreading into any other diencephalic area labeled a large number of neurons (estimated to be more than 9,000 in the case with the most neurons labeled) bilaterally at all levels of the spinal cord. Approximately 60% of the labeled neurons were contralateral to the injection. The greatest number of labeled neurons was found within the deep dorsal horn. Many were also found within the lateral spinal nucleus, the superficial dorsal horn, and the gray matter surrounding the central canal. A small number of labeled cells was located in the intermediate zone and ventral horn of the spinal gray matter. Labeled neurons were distributed bilaterally within the sacral parasympathetic nucleus and trigeminal nucleus caudalis. Injections of FG restricted to the medial hypothalamus labeled neurons within the spinal cord in a distribution similar to that produced by injections that filled the hypothalamus. However, fewer neurons were labeled in the spinal cord (estimated to be more than 6,200) and trigeminal nucleus caudalis. Injections of FG restricted to the lateral hypothalamus also labeled fewer neurons (approximately 3,300) than did injections that filled the hypothalamus. In these cases, also, the pattern of labeled neurons within the spinal cord was similar to that produced by injections within either medial or both medial and lateral hypothalamus. However, few neurons were labeled in the sacral parasympathetic nucleus following injections into the lateral hypothalamus. These findings show the distribution of a large number of spinal cord neurons that project directly to medial or lateral hypothalamic regions that are involved in autonomic, neuroendocrine, and emotional responses to somatosensory stimulation, including painful stimuli.

PubMed Disclaimer

Similar articles

• The cells of origin of the spinohypothalamic tract in cats.
  Katter JT, Burstein R, Giesler GJ Jr. Katter JT, et al. J Comp Neurol. 1991 Jan 1;303(1):101-12. doi: 10.1002/cne.903030109. J Comp Neurol. 1991. PMID: 1706361
• Retrograde labeling of neurons in the spinal cord that project directly to the amygdala or the orbital cortex in the rat.
  Burstein R, Potrebic S. Burstein R, et al. J Comp Neurol. 1993 Sep 22;335(4):469-85. doi: 10.1002/cne.903350402. J Comp Neurol. 1993. PMID: 8227531
• The organization of pudendal motoneurons and primary afferent projections in the spinal cord of the rhesus monkey revealed by horseradish peroxidase.
  Roppolo JR, Nadelhaft I, de Groat WC. Roppolo JR, et al. J Comp Neurol. 1985 Apr 22;234(4):475-88. doi: 10.1002/cne.902340406. J Comp Neurol. 1985. PMID: 3988996
• Localization of forebrain neurons which project directly to the medulla and spinal cord of the rat by retrograde tracing with wheat germ agglutinin.
  Schwanzel-Fukuda M, Morrell JI, Pfaff DW. Schwanzel-Fukuda M, et al. J Comp Neurol. 1984 Jun 10;226(1):1-20. doi: 10.1002/cne.902260102. J Comp Neurol. 1984. PMID: 6547458
• Spinal neuronal thermosensitivity in vivo and in vitro in relation to hypothalamic neuronal thermosensitivity.
  Simon E, Schmid HA, Pehl U. Simon E, et al. Prog Brain Res. 1998;115:25-47. doi: 10.1016/s0079-6123(08)62028-2. Prog Brain Res. 1998. PMID: 9632928 Review.

Cited by

• Responses of feline caudal hypothalamic cardiorespiratory neurons to hypoxia and hypercapnia.
  Dillon GH, Waldrop TG. Dillon GH, et al. Exp Brain Res. 1993;96(2):260-72. doi: 10.1007/BF00227106. Exp Brain Res. 1993. PMID: 8270021
• Ascending projections from the area around the spinal cord central canal: A Phaseolus vulgaris leucoagglutinin study in rats.
  Wang CC, Willis WD, Westlund KN. Wang CC, et al. J Comp Neurol. 1999 Dec 20;415(3):341-67. doi: 10.1002/(sici)1096-9861(19991220)415:3<341::aid-cne3>3.0.co;2-7. J Comp Neurol. 1999. PMID: 10553119 Free PMC article.
• Neural substrate of depression during migraine.
  Burstein R, Jakubowski M. Burstein R, et al. Neurol Sci. 2009 May;30 Suppl 1:S27-31. doi: 10.1007/s10072-009-0061-7. Neurol Sci. 2009. PMID: 19415422
• Quantitative analysis of spinothalamic tract neurons in adult and developing mouse.
  Davidson S, Truong H, Giesler GJ Jr. Davidson S, et al. J Comp Neurol. 2010 Aug 15;518(16):3193-204. doi: 10.1002/cne.22392. J Comp Neurol. 2010. PMID: 20575056 Free PMC article.
• Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes.
  Sun N, Perlman S. Sun N, et al. J Virol. 1995 Feb;69(2):633-41. doi: 10.1128/JVI.69.2.633-641.1995. J Virol. 1995. PMID: 7815526 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Wiley