Identification of fructose 3-phosphate in the lens of diabetic rats - PubMed (original) (raw)
Comparative Study
. 1990 Jan 26;247(4941):451-4.
doi: 10.1126/science.2300805.
Affiliations
- PMID: 2300805
- DOI: 10.1126/science.2300805
Comparative Study
Identification of fructose 3-phosphate in the lens of diabetic rats
B S Szwergold et al. Science. 1990.
Abstract
Fructose 3-phosphate, a novel monosaccharide phosphate, has been identified in the lens of diabetic rats. This compound, which is not present in normal lenses, is a protein glycosylating agent and enzyme inactivator. In addition, because of its structural features, this metabolite is relatively labile and undergoes hydrolysis to yield inorganic phosphate and the potent glycosylating agent, 3-deoxyglucosone. The increase in the concentration of fructose 3-phosphate in the lens of diabetic rats suggests that it and its hydrolysis product, 3-deoxyglucosone, may be responsible in part for the development of some diabetic complications in the lens.
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