Molecular components of the B-cell antigen receptor complex of the IgM class - PubMed (original) (raw)
. 1990 Feb 22;343(6260):760-2.
doi: 10.1038/343760a0.
Affiliations
- PMID: 2304550
- DOI: 10.1038/343760a0
Molecular components of the B-cell antigen receptor complex of the IgM class
J Hombach et al. Nature. 1990.
Abstract
The antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation. How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate a cell activation signal is not at present known. We now show that the IgM molecule is non-covalently associated in the membrane of B cells with two proteins of relative molecular mass 34,000 (Mr 34 K; IgM-alpha) and 39 K (Ig-beta) which form a disulphide-linked heterodimer. Surface expression of IgM seems to require the formation of an appropriate complex between IgM and the heterodimer. A transfection experiment indicates that IgM-alpha is the product of mb-1, a B-cell specific gene encoding a transmembrane protein with sequence homology to proteins of the T-cell antigen receptor-CD3 complex.
Similar articles
- Identification of the genes encoding the IgM-alpha and Ig-beta components of the IgM antigen receptor complex by amino-terminal sequencing.
Hombach J, Lottspeich F, Reth M. Hombach J, et al. Eur J Immunol. 1990 Dec;20(12):2795-9. doi: 10.1002/eji.1830201239. Eur J Immunol. 1990. PMID: 2269334 - The B cell antigen receptor of class IgD can be expressed on the cell surface in two different forms.
Wienands J, Reth M. Wienands J, et al. Eur J Immunol. 1991 Oct;21(10):2373-8. doi: 10.1002/eji.1830211012. Eur J Immunol. 1991. PMID: 1915550 - The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer.
Hartwig JH, Jugloff LS, De Groot NJ, Grupp SA, Jongstra-Bilen J. Hartwig JH, et al. J Immunol. 1995 Oct 15;155(8):3769-79. J Immunol. 1995. PMID: 7561081 - Antigen receptors on B lymphocytes.
Reth M. Reth M. Annu Rev Immunol. 1992;10:97-121. doi: 10.1146/annurev.iy.10.040192.000525. Annu Rev Immunol. 1992. PMID: 1591006 Review.
Cited by
- Towards a unifying model for B-cell receptor triggering.
Degn SE, Tolar P. Degn SE, et al. Nat Rev Immunol. 2024 Sep 10. doi: 10.1038/s41577-024-01073-x. Online ahead of print. Nat Rev Immunol. 2024. PMID: 39256626 Review. - In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function.
Estupiñán HY, Bouderlique T, He C, Berglöf A, Cappelleri A, Frengen N, Zain R, Karlsson MCI, Månsson R, Smith CIE. Estupiñán HY, et al. Blood Adv. 2024 Apr 23;8(8):1981-1990. doi: 10.1182/bloodadvances.2024012706. Blood Adv. 2024. PMID: 38507738 Free PMC article. - Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging.
Effer B, Perez I, Ulloa D, Mayer C, Muñoz F, Bustos D, Rojas C, Manterola C, Vergara-Gómez L, Dappolonnio C, Weber H, Leal P. Effer B, et al. Biomedicines. 2023 Jul 24;11(7):2086. doi: 10.3390/biomedicines11072086. Biomedicines. 2023. PMID: 37509725 Free PMC article. Review. - CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells.
Zheng Y, Yu M, Chen Y, Xue L, Zhu W, Fu G, Morris SW, Wen R, Wang D. Zheng Y, et al. J Immunol. 2023 May 1;210(9):1222-1235. doi: 10.4049/jimmunol.2200639. J Immunol. 2023. PMID: 36961449 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous