Retracted: Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes - PubMed (original) (raw)

doi: 10.1016/j.biomaterials.2012.09.037. Epub 2012 Oct 6.

Jinjin Shi, Hongling Zhang, Haixia Li, Yan Gao, Zhenzhen Wang, Honghong Wang, Lulu Li, Chaofeng Zhang, Chengqun Chen, Zhenzhong Zhang, Yun Zhang

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Retracted: Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes

Lei Wang et al. Biomaterials. 2013 Jan.

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Abstract

Single-walled carbon nanotubes (SWNTs) are special nano-materials which exhibit interesting physical and chemical properties, presenting new opportunities for biomedical research and applications. In this study, we have successfully adopted a novel strategy to chemically functionalize SWNTs with polyethylenimine (PEI) through purification, oxidation, amination and polymerization, which were then bound by DSPE-PEG2000-Maleimide for further conjugation with the tumor targeting NGR (Cys-Asn-Gly-Arg-Cys-) peptide via the maleimide group and sulfhydryl group of cysteine, and finally hTERT siRNA was loaded to obtain a novel tumor targeting siRNA delivery system, designated as SWNT-PEI/siRNA/NGR. The results showed that SWNT-PEI/siRNA/NGR could efficiently cross cell membrane, induced more severe apoptosis and stronger suppression in proliferation of PC-3 cells in vitro. Furthermore, in tumor-bearing mice model the delivery system exhibited higher antitumor activity due to more accumulation in tumor without obvious toxicity in main organs. The combination of RNAi and near-infrared (NIR) photothermal therapy significantly enhanced the therapeutic efficacy. In conclusion, SWNT-PEI/siRNA/NGR is a novel and promising anticancer system by combining gene therapy and photothermal therapy.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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