MR1 presents microbial vitamin B metabolites to MAIT cells - PubMed (original) (raw)
. 2012 Nov 29;491(7426):717-23.
doi: 10.1038/nature11605. Epub 2012 Oct 10.
Onisha Patel, Alexandra J Corbett, Jérôme Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard A J O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey
Affiliations
- PMID: 23051753
- DOI: 10.1038/nature11605
MR1 presents microbial vitamin B metabolites to MAIT cells
Lars Kjer-Nielsen et al. Nature. 2012.
Abstract
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells. Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1. Although the identity of MR1-restricted antigen(s) is unknown, it is present in numerous bacteria and yeast. Here we show that the structure and chemistry within the antigen-binding cleft of MR1 is distinct from the MHC and CD1 families. MR1 is ideally suited to bind ligands originating from vitamin metabolites. The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1. Furthermore, we characterize related MR1-restricted vitamin derivatives, originating from the bacterial riboflavin (vitamin B2) biosynthetic pathway, which specifically and potently activate MAIT cells. Accordingly, we show that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance. As many vitamin biosynthetic pathways are unique to bacteria and yeast, our data suggest that MAIT cells use these metabolites to detect microbial infection.
Comment in
- Immunology: Vitamins prime immunity.
Chua WJ, Hansen TH. Chua WJ, et al. Nature. 2012 Nov 29;491(7426):680-1. doi: 10.1038/491680a. Nature. 2012. PMID: 23192143 No abstract available. - Mucosal associated invariant T cells: don't forget your vitamins.
Young MH, Gapin L. Young MH, et al. Cell Res. 2013 Apr;23(4):460-2. doi: 10.1038/cr.2012.168. Epub 2012 Dec 4. Cell Res. 2013. PMID: 23208418 Free PMC article.
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