Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome - PubMed (original) (raw)
Review
. 2012 Dec;36(11-12):1009-31.
doi: 10.1111/apt.12080. Epub 2012 Oct 15.
Affiliations
- PMID: 23066886
- DOI: 10.1111/apt.12080
Free article
Review
Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome
J Matricon et al. Aliment Pharmacol Ther. 2012 Dec.
Free article
Abstract
Background: Irritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology. In recent years, numerous data have emerged that suggest the involvement of immune activation in IBS, at least in a subset of patients.
Aim: To determine whether immune activation and intestinal permeabilisation are more frequently observed in IBS patients compared with healthy controls.
Methods: The scientific bibliography was searched using the following keywords: irritable bowel syndrome, inflammation, immune activation, permeabilisation, intestine, assay, histology and human. The retrieved studies, including blood, faecal and histological studies, were analysed to provide a comprehensive and structured overview of the available data including the type of assay, type of inflammatory marker investigated or intestinal segment studied.
Results: Immune activation was more frequently observed in IBS patients than in healthy controls. An increase in the number of mast cells and lymphocytes, an alteration in cytokine levels and intestinal permeabilisation were reported in IBS patients. No consistent changes in the numbers of B cells or enterochromaffin cells or in mucosal serotonin production were demonstrated.
Conclusions: The changes observed were modest and often heterogeneous among the studied population. Only appropriate interventions improving irritable bowel syndrome symptoms could highlight and confirm the role of immune activation in this pathophysiology.
© 2012 Blackwell Publishing Ltd.
Comment in
- Commentary: associations between immune activation, intestinal permeability and irritable bowel syndrome.
Jovani M, Fiorino G, Danese S. Jovani M, et al. Aliment Pharmacol Ther. 2013 Jan;37(2):277-8. doi: 10.1111/apt.12136. Aliment Pharmacol Ther. 2013. PMID: 23252779 No abstract available. - Commentary: associations between immune activation, intestinal permeability and irritable bowel syndrome - author's reply.
Matricon J. Matricon J. Aliment Pharmacol Ther. 2013 Jan;37(2):278-9. doi: 10.1111/apt.12150. Aliment Pharmacol Ther. 2013. PMID: 23252780 No abstract available.
Similar articles
- Mucosal permeability and immune activation as potential therapeutic targets of probiotics in irritable bowel syndrome.
Barbara G, Zecchi L, Barbaro R, Cremon C, Bellacosa L, Marcellini M, De Giorgio R, Corinaldesi R, Stanghellini V. Barbara G, et al. J Clin Gastroenterol. 2012 Oct;46 Suppl:S52-5. doi: 10.1097/MCG.0b013e318264e918. J Clin Gastroenterol. 2012. PMID: 22955358 - Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms.
Cremon C, Gargano L, Morselli-Labate AM, Santini D, Cogliandro RF, De Giorgio R, Stanghellini V, Corinaldesi R, Barbara G. Cremon C, et al. Am J Gastroenterol. 2009 Feb;104(2):392-400. doi: 10.1038/ajg.2008.94. Epub 2009 Jan 13. Am J Gastroenterol. 2009. PMID: 19174797 - Mucosal immune cell numbers and visceral sensitivity in patients with irritable bowel syndrome: is there any relationship?
Braak B, Klooker TK, Wouters MM, Welting O, van der Loos CM, Stanisor OI, van Diest S, van den Wijngaard RM, Boeckxstaens GE. Braak B, et al. Am J Gastroenterol. 2012 May;107(5):715-26. doi: 10.1038/ajg.2012.54. Epub 2012 Apr 10. Am J Gastroenterol. 2012. PMID: 22488080 - Aminosalicylates and other anti-inflammatory compounds for irritable bowel syndrome.
Barbara G, Stanghellini V, Cremon C, De Giorgio R, Fronzoni L, Serra M, Corinaldesi R. Barbara G, et al. Dig Dis. 2009;27 Suppl 1:115-21. doi: 10.1159/000268131. Epub 2010 Mar 4. Dig Dis. 2009. PMID: 20203507 Review. - Immune response in irritable bowel syndrome: A systematic review of systemic and mucosal inflammatory mediators.
Martin-Viñas JJ, Quigley EM. Martin-Viñas JJ, et al. J Dig Dis. 2016 Sep;17(9):572-581. doi: 10.1111/1751-2980.12379. J Dig Dis. 2016. PMID: 27426409 Review.
Cited by
- Network pharmacology and experimental validation to explore the mechanism of Changji'an formula against irritable bowel syndrome with predominant diarrhea.
Ke W, Wu J, Li H, Huang S, Li H, Wang Y, Wu Y, Yuan J, Zhang S, Tang H, Lei K. Ke W, et al. Heliyon. 2024 Jun 17;10(12):e33102. doi: 10.1016/j.heliyon.2024.e33102. eCollection 2024 Jun 30. Heliyon. 2024. PMID: 39005919 Free PMC article. - The Role of Intestinal Barrier Function in Overweight Patients with IBS with Diarrhea Undergoing a Long-Term Low Fermentable Oligo-, Di-, and Monosaccharide and Polyol Diet.
Linsalata M, Riezzo G, Orlando A, D'Attoma B, Prospero L, Ignazzi A, Losurdo G, Di Leo A, Giannelli G, Russo F. Linsalata M, et al. Nutrients. 2023 Nov 4;15(21):4683. doi: 10.3390/nu15214683. Nutrients. 2023. PMID: 37960336 Free PMC article. - Low-level inflammation, immunity, and brain-gut axis in IBS: unraveling the complex relationships.
Yuan Y, Wang X, Huang S, Wang H, Shen G. Yuan Y, et al. Gut Microbes. 2023 Dec;15(2):2263209. doi: 10.1080/19490976.2023.2263209. Epub 2023 Oct 2. Gut Microbes. 2023. PMID: 37786296 Free PMC article. Review. - The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome.
Qu Y, Park SH, Dallas DC. Qu Y, et al. Nutrients. 2023 Sep 15;15(18):3991. doi: 10.3390/nu15183991. Nutrients. 2023. PMID: 37764775 Free PMC article. Review. - Diet in treatment of autism spectrum disorders.
Alam S, Westmark CJ, McCullagh EA. Alam S, et al. Front Neurosci. 2023 Jul 10;16:1031016. doi: 10.3389/fnins.2022.1031016. eCollection 2022. Front Neurosci. 2023. PMID: 37492195 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources