Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant - PubMed (original) (raw)
Randomized Controlled Trial
. 2012 Dec;130(6):1355-60.
doi: 10.1016/j.jaci.2012.09.003. Epub 2012 Oct 16.
Affiliations
- PMID: 23083673
- DOI: 10.1016/j.jaci.2012.09.003
Randomized Controlled Trial
Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant
Samuli Rautava et al. J Allergy Clin Immunol. 2012 Dec.
Abstract
Background: Probiotics have shown promising potential in reducing the risk of eczema in infants. Optimal probiotic intervention regimen remains to be determined.
Objective: We investigated whether maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of developing eczema in high-risk infants.
Methods: This was a parallel, double-blind placebo-controlled trial of 241 mother-infant pairs. Mothers with allergic disease and atopic sensitization were randomly assigned to receive (1) Lactobacillus rhamnosus LPR and Bifidobacterium longum BL999 (LPR+BL999), (2) L paracasei ST11 and B longum BL999 (ST11+BL999), or (3) placebo, beginning 2 months before delivery and during the first 2 months of breast-feeding. The infants were followed until the age of 24 months. Skin prick tests were performed at the ages of 6, 12, and 24 months.
Results: Altogether 205 infants completed the follow-up and were included in the analyses. The risk of developing eczema during the first 24 months of life was significantly reduced in infants of mothers receiving LPR+BL999 (odds ratio [OR], 0.17; 95% CI, 0.08-0.35; P < .001) and ST11+BL999 (OR, 0.16; 95% CI, 0.08-0.35; P < .001). The respective ORs for chronically persistent eczema were 0.30 (95% CI, 0.12-0.80; P = .016) and 0.17 (95% CI, 0.05-0.56; P = .003). Probiotics had no effect on the risk of atopic sensitization in the infants. No adverse effects were related to the use of probiotics.
Conclusion: Prevention regimen with specific probiotics administered to the pregnant and breast-feeding mother, that is, prenatally and postnatally, is safe and effective in reducing the risk of eczema in infants with allergic mothers positive for skin prick test.
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Comment in
- Reply: To PMID 23083673.
Rautava S, Kainonen E, Salminen S, Isolauri E. Rautava S, et al. J Allergy Clin Immunol. 2013 May;131(5):1447-8. doi: 10.1016/j.jaci.2013.01.056. Epub 2013 Mar 26. J Allergy Clin Immunol. 2013. PMID: 23538235 No abstract available. - Effect of probiotic supplementation during pregnancy and breast-feeding on the allergic sensitization in the infantile eczema.
Akelma AZ, Mete E, Bozkurt B. Akelma AZ, et al. J Allergy Clin Immunol. 2013 May;131(5):1447. doi: 10.1016/j.jaci.2013.01.055. Epub 2013 Mar 26. J Allergy Clin Immunol. 2013. PMID: 23538236 No abstract available.
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