Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies - PubMed (original) (raw)
Review
Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies
A Vita et al. Transl Psychiatry. 2012.
Erratum in
- Transl Psychiatry. 2013;3:e275
Abstract
Cortical gray matter deficits have been found in patients with schizophrenia, with evidence of progression over time. The aim of this study was to determine the extent of progressive cortical gray matter volume changes over time in schizophrenia, their site and time of occurrence, and the role of potential moderators of brain changes. English language articles published between 1 January 1983 and 31 March 2012 in the MEDLINE and EMBASE databases were searched. Longitudinal magnetic resonance imaging studies comparing changes in cortical gray matter volume over time between patients with schizophrenia and healthy controls were included. Hedges g was calculated for each study. Analyses were performed using fixed- and random-effects models. A subgroup analysis was run to explore the pattern of brain changes in patients with first-episode schizophrenia. A meta-regression statistic was adopted to investigate the role of potential moderators of the effect sizes (ESs). A total of 19 studies, analyzing 813 patients with schizophrenia and 718 healthy controls, were included. Over time, patients with schizophrenia showed a significantly higher volume loss of total cortical gray matter, left superior temporal gyrus (STG), left anterior STG, left Heschl gyrus, left planum temporale and posterior STG bilaterally. Meta-analysis of first-episode schizophrenic patients showed a more significant pattern of progressive loss of whole cerebral gray matter volume involving the frontal, temporal and parietal lobes, and left Heschl gyrus compared with healthy controls. Clinical, pharmacologic and neuroradiological variables were found to be significant moderators of brain volume changes in patients with schizophrenia. The meta-analysis demonstrates that progressive cortical gray matter changes in schizophrenia occur with regional and temporal specificity. The underlying pathological process appears to be especially active in the first stages of the disease, affects the left hemisphere and the superior temporal structures more and is at least partly moderated by the type of pharmacological treatment received.
Figures
Figure 1
Flowchart of study selection.
Similar articles
- The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies.
Vita A, De Peri L, Deste G, Barlati S, Sacchetti E. Vita A, et al. Biol Psychiatry. 2015 Sep 15;78(6):403-12. doi: 10.1016/j.biopsych.2015.02.008. Epub 2015 Feb 16. Biol Psychiatry. 2015. PMID: 25802081 - Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Spencer MH, Yurgelun-Todd DA, Kikinis R, Jolesz FA, McCarley RW. Kasai K, et al. Arch Gen Psychiatry. 2003 Aug;60(8):766-75. doi: 10.1001/archpsyc.60.8.766. Arch Gen Psychiatry. 2003. PMID: 12912760 Free PMC article. - A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia.
Takahashi T, Suzuki M, Zhou SY, Tanino R, Nakamura K, Kawasaki Y, Seto H, Kurachi M. Takahashi T, et al. Schizophr Res. 2010 Jun;119(1-3):65-74. doi: 10.1016/j.schres.2009.12.006. Epub 2010 Jan 3. Schizophr Res. 2010. PMID: 20051316 - Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems: A Meta-analysis.
Rogers JC, De Brito SA. Rogers JC, et al. JAMA Psychiatry. 2016 Jan;73(1):64-72. doi: 10.1001/jamapsychiatry.2015.2423. JAMA Psychiatry. 2016. PMID: 26650724 Review. - Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.
Kuo SS, Pogue-Geile MF. Kuo SS, et al. Neurosci Biobehav Rev. 2019 Mar;98:85-94. doi: 10.1016/j.neubiorev.2018.12.030. Epub 2019 Jan 4. Neurosci Biobehav Rev. 2019. PMID: 30615934 Free PMC article. Review.
Cited by
- Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise.
Sapienza J, Agostoni G, Comai S, Nasini S, Dall'Acqua S, Sut S, Spangaro M, Martini F, Bechi M, Buonocore M, Bigai G, Repaci F, Nocera D, Ave C, Guglielmino C, Cocchi F, Cavallaro R, Deste G, Bosia M. Sapienza J, et al. Schizophr Res Cogn. 2024 Aug 29;38:100328. doi: 10.1016/j.scog.2024.100328. eCollection 2024 Dec. Schizophr Res Cogn. 2024. PMID: 39281320 Free PMC article. - Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks.
Bracher KM, Wohlschlaeger A, Koch K, Knolle F. Bracher KM, et al. Sci Rep. 2024 Sep 2;14(1):20314. doi: 10.1038/s41598-024-71316-3. Sci Rep. 2024. PMID: 39223185 Free PMC article. - Effects of Adapted Physical Activity on White Matter Integrity in Patients with Schizophrenia.
Leroux E, Masson L, Tréhout M, Dollfus S. Leroux E, et al. Brain Sci. 2024 Jul 15;14(7):710. doi: 10.3390/brainsci14070710. Brain Sci. 2024. PMID: 39061450 Free PMC article. - Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis.
Hua JPY, Abram SV, Loewy RL, Stuart B, Fryer SL, Vinogradov S, Mathalon DH. Hua JPY, et al. Schizophr Bull. 2024 Aug 27;50(5):1159-1170. doi: 10.1093/schbul/sbae074. Schizophr Bull. 2024. PMID: 38815987 - Longitudinal assessment of ventricular volume trajectories in early-stage schizophrenia: evidence of both enlargement and shrinkage.
Svancer P, Capek V, Skoch A, Kopecek M, Vochoskova K, Fialova M, Furstova P, Jakob L, Bakstein E, Kolenic M, Hlinka J, Knytl P, Spaniel F. Svancer P, et al. BMC Psychiatry. 2024 Apr 24;24(1):309. doi: 10.1186/s12888-024-05749-5. BMC Psychiatry. 2024. PMID: 38658884 Free PMC article.
References
- Ward KE, Friedman L, Wise A, Schulz SC. Meta-analysis of brain and cranial size in schizophrenia. Schizophr Res. 1996;22:197–213. - PubMed
- Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry. 1988;55:433–440. - PubMed
- Wrigh IC, Rabe-Hesketh S, Woodruff PWR, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry. 2000;157:16–25. - PubMed
- Vita A, De Peri L, Silenzi C, Dieci M. Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophr Res. 2006;82:75–88. - PubMed
- Keshavan M, Haas GL, Kahn CE, Aguilar E, Dick EL, Schooler NR, et al. Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible. Psychiatry Res. 1998;32:161–167. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical