Normoalbuminuric diabetic kidney disease in the U.S. population - PubMed (original) (raw)

Normoalbuminuric diabetic kidney disease in the U.S. population

Amy K Mottl et al. J Diabetes Complications. 2013 Mar-Apr.

Abstract

Background: This study sought to compare the prevalence and modifying factors of normoalbuminuric (NA) versus albuminuric (ALB) CKD in the U.S. diabetic and nondiabetic populations.

Methods: NHANES 2001-2008 included 2798 diabetic and 15,743 nondiabetic participants. Age-specific prevalence of NA-CKD and ALB-CKD was calculated within each diabetes stratum and then stratified again according to gender, ethnicity, mean arterial pressure ≥105 mmHg and HbA1c≥7%. Multivariate regression analyses were performed to determine odds ratios and 95% CI for NA-CKD.

Results: Prevalence of NA-CKD rose with age, with an overall mean of 9.7% in diabetic and 4.3% in nondiabetic participants. NA-CKD was less prevalent in diabetic men, OR=0.58 (95% CI: 0.39, 0.87). In comparison with whites, blacks and 'other' ethnic groups had an OR for NA-CKD of 0.44 (95% CI 0.29, 0.68) and 0.57 (95% CI: 0.34, 0.96), respectively. Poorly controlled blood pressure and glycemia resulted in a decreased OR for NA-CKD (OR = 0.25, 95% CI: 0.13, 0.50) and (0.48, 95% CI: 0.31, 0.74), respectively. Similar results were obtained for nondiabetic participants.

Conclusions: NA-CKD is more common in people with diabetes, women, non-Hispanic whites, and in the setting of well controlled blood pressure and glycemia.

Copyright © 2013 Elsevier Inc. All rights reserved.

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Conflict of interest statement

Conflict of Interest: none.

Figures

Fig. 1

Fig. 1

Algorithm and participant numbers meeting selection criteria for study of chronic kidney disease (eGFR<60ml/min/1.73m2) with albuminuria (ALB) ≥30mg/g and normoalbuminuria (NA) <30mg/g in NHANES 2001–2008.

Fig. 2

Fig. 2

Age-specific prevalence of chronic kidney disease (CKD) defined as eGFR <60ml/min/1.73m2 according to diabetes status and albuminuria (ALB) ≥30mg/g or normoalbuminuria (NA) <30mg/g on a random urine specimen from NHANES 2001–2008.

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