Yin and yang of mediator function revealed by human mutants - PubMed (original) (raw)

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Yin and yang of mediator function revealed by human mutants

Arnold J Berk. Proc Natl Acad Sci U S A. 2012.

No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.

Diagram representing simultaneous binding of several regulatory TF activation domains to different surfaces of the Mediator. dsDNA is represented by a thin blue line and histone octamers by orange discs. Regulatory TFs bind to specific DNA sequences at promoter proximal regions (bottom left of Mediator) and distal enhancers (top of Mediator) via their DNA-binding domains (blue), which are linked through flexible regions of polypeptide to activation domains (green). In response to interactions with activation domains, Mediator binds to RNA Pol II and promotes binding of the polymerase and its general TFs to the TSS. [Reprinted with permission from W. H. Freeman and Company (21).]

Comment on

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