Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption of serum with non-type-specific cell wall polysaccharide - PubMed (original) (raw)
Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption of serum with non-type-specific cell wall polysaccharide
D M Musher et al. J Infect Dis. 1990 Apr.
Abstract
Available pneumococcal vaccines provide only limited protection for certain at-risk populations. Fifteen healthy young adults and 11 older chronic bronchitics received 23-valent pneumococcal vaccine. ELISA showed that IgG reactive with capsular polysaccharides from Streptococcus pneumoniae serotypes 3, 4, 8, 14, and 19F increased after vaccination. Bronchitics exhibited lesser responses for four of these serotypes, although differences between the groups were significant only for serotype 3. Adsorption of postvaccination sera with pneumococcal cell wall polysaccharide significantly reduced mean antibody levels in both groups and lowered the proportion of sera that demonstrated type-specific antibody responses. Reactive IgG was largely restricted to the IgG2 subclass. Pneumococcal vaccine may provide suboptimal protection of older adults because antibody responses to some capsular polysaccharides are lower in elderly bronchitics than in healthy young adults. A substantial proportion of measured antibody reflects IgG reactive with cell wall polysaccharides rather than with type-specific, capsular constituents, suggesting that antibody responses in subjects of all ages deserve reappraisal.
Similar articles
- [An immunoenzymatic test for IgG antibody levels against 10 serotypes of Streptococcus pneumoniae].
Leal-Esteban LC, Rojas JL, Jaimes AL, Montoya JD, Montoya NE, Leiva L, Trujillo-Vargas CM. Leal-Esteban LC, et al. Biomedica. 2012 Jan-Mar;32(1):92-102. doi: 10.1590/S0120-41572012000100011. Biomedica. 2012. PMID: 23235791 Spanish. - Immunogenicity differences of a 15-valent pneumococcal polysaccharide conjugate vaccine (PCV15) based on vaccine dose, route of immunization and mouse strain.
Caro-Aguilar I, Indrawati L, Kaufhold RM, Gaunt C, Zhang Y, Nawrocki DK, Giovarelli C, Winters MA, Smith WJ, Heinrichs J, Skinner JM. Caro-Aguilar I, et al. Vaccine. 2017 Feb 7;35(6):865-872. doi: 10.1016/j.vaccine.2016.12.055. Epub 2017 Jan 10. Vaccine. 2017. PMID: 28087148 Review. - Studies on vaccine control and immunogenicity of polysaccharides of Streptococcus pneumoniae.
Lee CJ, Lin KT. Lee CJ, et al. Rev Infect Dis. 1981 Mar-Apr;3 Suppl:S51-60. doi: 10.1093/clinids/3.supplement_1.s51. Rev Infect Dis. 1981. PMID: 6169130 Review.
Cited by
- The Microbial Etiology of Community-Acquired Pneumonia in Adults: from Classical Bacteriology to Host Transcriptional Signatures.
Gadsby NJ, Musher DM. Gadsby NJ, et al. Clin Microbiol Rev. 2022 Dec 21;35(4):e0001522. doi: 10.1128/cmr.00015-22. Epub 2022 Sep 27. Clin Microbiol Rev. 2022. PMID: 36165783 Free PMC article. Review. - Immunobiology of Carbohydrates: Implications for Novel Vaccine and Adjuvant Design Against Infectious Diseases.
Stefanetti G, Borriello F, Richichi B, Zanoni I, Lay L. Stefanetti G, et al. Front Cell Infect Microbiol. 2022 Jan 18;11:808005. doi: 10.3389/fcimb.2021.808005. eCollection 2021. Front Cell Infect Microbiol. 2022. PMID: 35118012 Free PMC article. Review. - Pneumococcal Vaccination Strategies Among HIV-infected Adult Patients: A Review of the Literature.
Garmpi A, Damaskos C, Garmpis N, Patsouras A, Savvanis S, Gravvanis N, Diamantis E. Garmpi A, et al. In Vivo. 2019 Sep-Oct;33(5):1425-1430. doi: 10.21873/invivo.11620. In Vivo. 2019. PMID: 31471388 Free PMC article. Review. - Race-related differences in functional antibody response to pneumococcal vaccination in HIV-infected individuals.
Happe M, Samuvel DJ, Ohtola JA, Korte JE, Westerink MAJ. Happe M, et al. Vaccine. 2019 Mar 14;37(12):1622-1629. doi: 10.1016/j.vaccine.2019.01.084. Epub 2019 Feb 21. Vaccine. 2019. PMID: 30797636 Free PMC article. - VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.
Conrad A, Boccard M, Valour F, Alcazer V, Tovar Sanchez AT, Chidiac C, Laurent F, Vanhems P, Salles G, Brengel-Pesce K, Meunier B, Trouillet-Assant S, Ader F; Lyon HEMINF Study Group. Conrad A, et al. BMJ Open. 2019 Feb 15;9(2):e026093. doi: 10.1136/bmjopen-2018-026093. BMJ Open. 2019. PMID: 30772864 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical