Integrated-optics-based swept-source optical coherence tomography - PubMed (original) (raw)

. 2012 Dec 1;37(23):4820-2.

doi: 10.1364/OL.37.004820.

Affiliations

• PMID: 23202057
• DOI: 10.1364/OL.37.004820

Integrated-optics-based swept-source optical coherence tomography

V Duc Nguyen et al. Opt Lett. 2012.

Abstract

We designed, fabricated, and characterized an integrated-optics-based swept-source optical coherence tomography (SS-OCT) system in TriPleX technology. An external 1300 nm swept source is coupled to the chip, which contains waveguide structures for interferometric depth ranging and balanced detection. The complete OCT chip has a footprint of 0.4 cm × 1.8 cm. Light from the chip is focused onto the sample using an aspheric lens; the lateral resolution is 21±1 μm. OCT measurements, performed with a moveable mirror, demonstrate a sensitivity of -80 dB and imaging up to the maximum depth of 5.09 mm. Corrected for dispersion, the measured OCT axial resolution of 12.7±0.5 μm is in good agreement with the bandwidth limited resolution. Finally, we demonstrate cross-sectional OCT imaging of a multilayered tissue phantom over the whole depth range with the integrated-optics-based SS-OCT system.

PubMed Disclaimer

Similar articles

• Spectral domain optical coherence tomography imaging with an integrated optics spectrometer.
  Nguyen VD, Akca BI, Wörhoff K, de Ridder RM, Pollnau M, van Leeuwen TG, Kalkman J. Nguyen VD, et al. Opt Lett. 2011 Apr 1;36(7):1293-5. doi: 10.1364/OL.36.001293. Opt Lett. 2011. PMID: 21479062
• Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography.
  Yurtsever G, Weiss N, Kalkman J, van Leeuwen TG, Baets R. Yurtsever G, et al. Opt Lett. 2014 Sep 1;39(17):5228-31. doi: 10.1364/OL.39.005228. Opt Lett. 2014. PMID: 25166116
• Wide tuning range wavelength-swept laser with a single SOA at 1020 nm for ultrahigh resolution Fourier-domain optical coherence tomography.
  Lee SW, Song HW, Jung MY, Kim SH. Lee SW, et al. Opt Express. 2011 Oct 24;19(22):21227-37. doi: 10.1364/OE.19.021227. Opt Express. 2011. PMID: 22108975
• Spectral domain optical coherence tomography: a better OCT imaging strategy.
  Yaqoob Z, Wu J, Yang C. Yaqoob Z, et al. Biotechniques. 2005 Dec;39(6 Suppl):S6-13. doi: 10.2144/000112090. Biotechniques. 2005. PMID: 20158503 Review.
• Adaptive optics optical coherence tomography in glaucoma.
  Dong ZM, Wollstein G, Wang B, Schuman JS. Dong ZM, et al. Prog Retin Eye Res. 2017 Mar;57:76-88. doi: 10.1016/j.preteyeres.2016.11.001. Epub 2016 Dec 1. Prog Retin Eye Res. 2017. PMID: 27916682 Free PMC article. Review.

Cited by

• In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit.
  Rank EA, Nevlacsil S, Muellner P, Hainberger R, Salas M, Gloor S, Duelk M, Sagmeister M, Kraft J, Leitgeb RA, Drexler W. Rank EA, et al. Sci Rep. 2021 Oct 26;11(1):21052. doi: 10.1038/s41598-021-00637-4. Sci Rep. 2021. PMID: 34702941 Free PMC article.
• Cubic meter volume optical coherence tomography.
  Wang Z, Potsaid B, Chen L, Doerr C, Lee HC, Nielson T, Jayaraman V, Cable AE, Swanson E, Fujimoto JG. Wang Z, et al. Optica. 2016 Dec;3(12):1496-1503. doi: 10.1364/OPTICA.3.001496. Epub 2016 Dec 15. Optica. 2016. PMID: 28239628 Free PMC article.
• Methods to assess sensitivity of optical coherence tomography systems.
  Agrawal A, Pfefer TJ, Woolliams PD, Tomlins PH, Nehmetallah G. Agrawal A, et al. Biomed Opt Express. 2017 Jan 18;8(2):902-917. doi: 10.1364/BOE.8.000902. eCollection 2017 Feb 1. Biomed Opt Express. 2017. PMID: 28270992 Free PMC article.
• Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications.
  Dsouza R, Won J, Monroy GL, Spillman DR, Boppart SA. Dsouza R, et al. J Biomed Opt. 2018 Sep;23(9):1-11. doi: 10.1117/1.JBO.23.9.096003. J Biomed Opt. 2018. PMID: 30251484 Free PMC article.
• Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection.
  Wang Z, Lee HC, Vermeulen D, Chen L, Nielsen T, Park SY, Ghaemi A, Swanson E, Doerr C, Fujimoto J. Wang Z, et al. Biomed Opt Express. 2015 Jun 17;6(7):2562-74. doi: 10.1364/BOE.6.002562. eCollection 2015 Jul 1. Biomed Opt Express. 2015. PMID: 26203382 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Optica Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal