Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort - PubMed (original) (raw)
. 2013 Feb 15;207(4):622-7.
doi: 10.1093/infdis/jis732. Epub 2012 Nov 29.
Juliette Bitard, Estibaliz Lazaro, Didier Neau, Fabrice Bonnet, Patrick Mercie, Michel Dupon, Mojgan Hessamfar, Michel Ventura, Denis Malvy, François Dabis, Jean-Luc Pellegrin, Jean-François Moreau, Rodolphe Thiébaut, Isabelle Pellegrin; Groupe d'Epidémiologie Clinique du SIDA en Aquitaine
Collaborators, Affiliations
- PMID: 23204178
- DOI: 10.1093/infdis/jis732
Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort
Linda Wittkop et al. J Infect Dis. 2013.
Abstract
We evaluated the impact of cytomegalovirus (CMV)-induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1-infected patients from the ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt of combination antiretroviral therapy (cART). HLA-DR(+)/CD38(+) expression was 16.8% among CD8(+) T cells. Independent of age, CD4(+) T-cell count, 16S ribosomal DNA load, and regulatory T-cell count, positive results of Quantiferon CMV analysis (P = .02), positive results of CMV-pp65 enzyme-linked immunosorbent spot analysis (P = .01), positive results of CMV-pp65-specific CD8(+) T-cell analysis (P = .05), and CMV seropositivity (P = .01) were associated with a higher percentage of CD8+ T cells that expressed HLA-DR+/CD38+. Autoimmune response and microbial translocation were not associated with immune activation. Therefore, the CMV-induced immune response seems to be associated with chronic immune activation in cART recipients with sustained virological suppression.
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