Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study - PubMed (original) (raw)
Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study
P R Lowenstein et al. Brain Res. 1990.
Free article
Abstract
The distribution of cholinergic pre- and postsynaptic markers and dopaminergic presynaptic markers was analyzed in the adult human striatum, using quantitative receptor autoradiography. The distribution of the different binding sites indicates that cholinergic and dopaminergic uptake sites display a striosomal organization, with a higher binding site density in the striatal matrix. M1 muscarinic cholinergic receptor distribution parallels the distribution of cholinergic presynaptic markers. Our data show that cholinergic and dopaminergic terminals, and M1 receptors are enriched in the matrix of the adult human striatum.
Similar articles
- Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study.
Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Raskin LS, Price DL, Coyle JT. Lowenstein PR, et al. J Comp Neurol. 1989 Oct 15;288(3):428-46. doi: 10.1002/cne.902880306. J Comp Neurol. 1989. PMID: 2794143 - Intrastriatal grafts derived from fetal striatal primordia: II. Reconstitution of cholinergic and dopaminergic systems.
Liu FC, Graybiel AM, Dunnett SB, Baughman RW. Liu FC, et al. J Comp Neurol. 1990 May 1;295(1):1-14. doi: 10.1002/cne.902950102. J Comp Neurol. 1990. PMID: 1971286 - Cholinergic interneuron characteristics and nicotinic properties in the striatum.
Zhou FM, Wilson CJ, Dani JA. Zhou FM, et al. J Neurobiol. 2002 Dec;53(4):590-605. doi: 10.1002/neu.10150. J Neurobiol. 2002. PMID: 12436423 Review.
Cited by
- A comparison of behaviour following stimulation of the anterior substantia nigra by direct cholinergic agonists and anticholinesterases.
Parker GC, Inglis WL, Winn P. Parker GC, et al. Psychopharmacology (Berl). 1993;112(2-3):242-8. doi: 10.1007/BF02244917. Psychopharmacology (Berl). 1993. PMID: 7871026 - The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine.
Joyce JN. Joyce JN. Psychopharmacology (Berl). 1993;112(1 Suppl):S16-34. doi: 10.1007/BF02245004. Psychopharmacology (Berl). 1993. PMID: 7831438 Review. - Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.
Graybiel AM, Moratalla R, Robertson HA. Graybiel AM, et al. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6912-6. doi: 10.1073/pnas.87.17.6912. Proc Natl Acad Sci U S A. 1990. PMID: 2118661 Free PMC article. - Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW, Graybiel AM. Moratalla R, et al. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3859-63. doi: 10.1073/pnas.89.9.3859. Proc Natl Acad Sci U S A. 1992. PMID: 1570304 Free PMC article. - Compartmentalization of excitatory amino acid receptors in human striatum.
Dure LS 4th, Young AB, Penney JB Jr. Dure LS 4th, et al. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7688-92. doi: 10.1073/pnas.89.16.7688. Proc Natl Acad Sci U S A. 1992. PMID: 1380163 Free PMC article.