EMT and MET in metastasis: where are the cancer stem cells? - PubMed (original) (raw)

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. 2012 Dec 11;22(6):699-701.

doi: 10.1016/j.ccr.2012.11.009.

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• PMID: 23238008
• DOI: 10.1016/j.ccr.2012.11.009

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EMT and MET in metastasis: where are the cancer stem cells?

Thomas Brabletz. Cancer Cell. 2012.

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Abstract

Activation of epithelial-mesenchymal transition (EMT) is important for cancer cell dissemination. Two papers in this issue of Cancer Cell (Ocaña and colleagues and Tsai and colleagues) support the concept that the reversal of EMT is necessary for efficient metastatic colonization. Moreover, although EMT has been associated with stemness properties, one study indicates that they are not necessarily linked.

Copyright © 2012 Elsevier Inc. All rights reserved.

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• Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
  Ocaña OH, Córcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A, Nieto MA. Ocaña OH, et al. Cancer Cell. 2012 Dec 11;22(6):709-24. doi: 10.1016/j.ccr.2012.10.012. Epub 2012 Nov 29. Cancer Cell. 2012. PMID: 23201163

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