Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 - PubMed (original) (raw)

. 2012 Dec 15;380(9859):2095-128.

doi: 10.1016/S0140-6736(12)61728-0.

Mohsen Naghavi, Kyle Foreman, Stephen Lim, Kenji Shibuya, Victor Aboyans, Jerry Abraham, Timothy Adair, Rakesh Aggarwal, Stephanie Y Ahn, Miriam Alvarado, H Ross Anderson, Laurie M Anderson, Kathryn G Andrews, Charles Atkinson, Larry M Baddour, Suzanne Barker-Collo, David H Bartels, Michelle L Bell, Emelia J Benjamin, Derrick Bennett, Kavi Bhalla, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, Fiona Blyth, Ian Bolliger, Soufiane Boufous, Chiara Bucello, Michael Burch, Peter Burney, Jonathan Carapetis, Honglei Chen, David Chou, Sumeet S Chugh, Luc E Coffeng, Steven D Colan, Samantha Colquhoun, K Ellicott Colson, John Condon, Myles D Connor, Leslie T Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C Cowie, Michael H Criqui, Marita Cross, Kaustubh C Dabhadkar, Nabila Dahodwala, Diego De Leo, Louisa Degenhardt, Allyne Delossantos, Julie Denenberg, Don C Des Jarlais, Samath D Dharmaratne, E Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Patricia J Erwin, Patricia Espindola, Majid Ezzati, Valery Feigin, Abraham D Flaxman, Mohammad H Forouzanfar, Francis Gerry R Fowkes, Richard Franklin, Marlene Fransen, Michael K Freeman, Sherine E Gabriel, Emmanuela Gakidou, Flavio Gaspari, Richard F Gillum, Diego Gonzalez-Medina, Yara A Halasa, Diana Haring, James E Harrison, Rasmus Havmoeller, Roderick J Hay, Bruno Hoen, Peter J Hotez, Damian Hoy, Kathryn H Jacobsen, Spencer L James, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Ganesan Karthikeyan, Nicholas Kassebaum, Andre Keren, Jon-Paul Khoo, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Michael Lipnick, Steven E Lipshultz, Summer Lockett Ohno, Jacqueline Mabweijano, Michael F MacIntyre, Leslie Mallinger, Lyn March, Guy B Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M Mayosi, John H McAnulty, Mary M McDermott, John McGrath, George A Mensah, Tony R Merriman, Catherine Michaud, Matthew Miller, Ted R Miller, Charles Mock, Ana Olga Mocumbi, Ali A Mokdad, Andrew Moran, Kim Mulholland, M Nathan Nair, Luigi Naldi, K M Venkat Narayan, Kiumarss Nasseri, Paul Norman, Martin O'Donnell, Saad B Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, David Phillips, Kelsey Pierce, C Arden Pope 3rd, Esteban Porrini, Farshad Pourmalek, Murugesan Raju, Dharani Ranganathan, Jürgen T Rehm, David B Rein, Guiseppe Remuzzi, Frederick P Rivara, Thomas Roberts, Felipe Rodriguez De León, Lisa C Rosenfeld, Lesley Rushton, Ralph L Sacco, Joshua A Salomon, Uchechukwu Sampson, Ella Sanman, David C Schwebel, Maria Segui-Gomez, Donald S Shepard, David Singh, Jessica Singleton, Karen Sliwa, Emma Smith, Andrew Steer, Jennifer A Taylor, Bernadette Thomas, Imad M Tleyjeh, Jeffrey A Towbin, Thomas Truelsen, Eduardo A Undurraga, N Venketasubramanian, Lakshmi Vijayakumar, Theo Vos, Gregory R Wagner, Mengru Wang, Wenzhi Wang, Kerrianne Watt, Martin A Weinstock, Robert Weintraub, James D Wilkinson, Anthony D Woolf, Sarah Wulf, Pon-Hsiu Yeh, Paul Yip, Azadeh Zabetian, Zhi-Jie Zheng, Alan D Lopez, Christopher J L Murray, Mohammad A AlMazroa, Ziad A Memish

Affiliations

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Rafael Lozano et al. Lancet. 2012.

Erratum in

Abstract

Background: Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex.

Methods: We attempted to identify all available data on causes of death for 187 countries from 1980 to 2010 from vital registration, verbal autopsy, mortality surveillance, censuses, surveys, hospitals, police records, and mortuaries. We assessed data quality for completeness, diagnostic accuracy, missing data, stochastic variations, and probable causes of death. We applied six different modelling strategies to estimate cause-specific mortality trends depending on the strength of the data. For 133 causes and three special aggregates we used the Cause of Death Ensemble model (CODEm) approach, which uses four families of statistical models testing a large set of different models using different permutations of covariates. Model ensembles were developed from these component models. We assessed model performance with rigorous out-of-sample testing of prediction error and the validity of 95% UIs. For 13 causes with low observed numbers of deaths, we developed negative binomial models with plausible covariates. For 27 causes for which death is rare, we modelled the higher level cause in the cause hierarchy of the GBD 2010 and then allocated deaths across component causes proportionately, estimated from all available data in the database. For selected causes (African trypanosomiasis, congenital syphilis, whooping cough, measles, typhoid and parathyroid, leishmaniasis, acute hepatitis E, and HIV/AIDS), we used natural history models based on information on incidence, prevalence, and case-fatality. We separately estimated cause fractions by aetiology for diarrhoea, lower respiratory infections, and meningitis, as well as disaggregations by subcause for chronic kidney disease, maternal disorders, cirrhosis, and liver cancer. For deaths due to collective violence and natural disasters, we used mortality shock regressions. For every cause, we estimated 95% UIs that captured both parameter estimation uncertainty and uncertainty due to model specification where CODEm was used. We constrained cause-specific fractions within every age-sex group to sum to total mortality based on draws from the uncertainty distributions.

Findings: In 2010, there were 52·8 million deaths globally. At the most aggregate level, communicable, maternal, neonatal, and nutritional causes were 24·9% of deaths worldwide in 2010, down from 15·9 million (34·1%) of 46·5 million in 1990. This decrease was largely due to decreases in mortality from diarrhoeal disease (from 2·5 to 1·4 million), lower respiratory infections (from 3·4 to 2·8 million), neonatal disorders (from 3·1 to 2·2 million), measles (from 0·63 to 0·13 million), and tetanus (from 0·27 to 0·06 million). Deaths from HIV/AIDS increased from 0·30 million in 1990 to 1·5 million in 2010, reaching a peak of 1·7 million in 2006. Malaria mortality also rose by an estimated 19·9% since 1990 to 1·17 million deaths in 2010. Tuberculosis killed 1·2 million people in 2010. Deaths from non-communicable diseases rose by just under 8 million between 1990 and 2010, accounting for two of every three deaths (34·5 million) worldwide by 2010. 8 million people died from cancer in 2010, 38% more than two decades ago; of these, 1·5 million (19%) were from trachea, bronchus, and lung cancer. Ischaemic heart disease and stroke collectively killed 12·9 million people in 2010, or one in four deaths worldwide, compared with one in five in 1990; 1·3 million deaths were due to diabetes, twice as many as in 1990. The fraction of global deaths due to injuries (5·1 million deaths) was marginally higher in 2010 (9·6%) compared with two decades earlier (8·8%). This was driven by a 46% rise in deaths worldwide due to road traffic accidents (1·3 million in 2010) and a rise in deaths from falls. Ischaemic heart disease, stroke, chronic obstructive pulmonary disease (COPD), lower respiratory infections, lung cancer, and HIV/AIDS were the leading causes of death in 2010. Ischaemic heart disease, lower respiratory infections, stroke, diarrhoeal disease, malaria, and HIV/AIDS were the leading causes of years of life lost due to premature mortality (YLLs) in 2010, similar to what was estimated for 1990, except for HIV/AIDS and preterm birth complications. YLLs from lower respiratory infections and diarrhoea decreased by 45-54% since 1990; ischaemic heart disease and stroke YLLs increased by 17-28%. Regional variations in leading causes of death were substantial. Communicable, maternal, neonatal, and nutritional causes still accounted for 76% of premature mortality in sub-Saharan Africa in 2010. Age standardised death rates from some key disorders rose (HIV/AIDS, Alzheimer's disease, diabetes mellitus, and chronic kidney disease in particular), but for most diseases, death rates fell in the past two decades; including major vascular diseases, COPD, most forms of cancer, liver cirrhosis, and maternal disorders. For other conditions, notably malaria, prostate cancer, and injuries, little change was noted.

Interpretation: Population growth, increased average age of the world's population, and largely decreasing age-specific, sex-specific, and cause-specific death rates combine to drive a broad shift from communicable, maternal, neonatal, and nutritional causes towards non-communicable diseases. Nevertheless, communicable, maternal, neonatal, and nutritional causes remain the dominant causes of YLLs in sub-Saharan Africa. Overlaid on this general pattern of the epidemiological transition, marked regional variation exists in many causes, such as interpersonal violence, suicide, liver cancer, diabetes, cirrhosis, Chagas disease, African trypanosomiasis, melanoma, and others. Regional heterogeneity highlights the importance of sound epidemiological assessments of the causes of death on a regular basis.

Funding: Bill & Melinda Gates Foundation.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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Conflict of interest statement

Conflicts of interest

E R Dorsey has received consulting fees from Medtronic and Lundbeck and research support from Lundbeck and Prana Biotechnology. M Ezzati chaired a session and gave a talk at the World Cardiology Congress (WCC), with travel cost reimbursed by the World Heart Federation. At the WCC, he also gave a talk at a session organised by PepsiCo with no financial or other renumeration. P J Hotez reports holding several positions: Dean, National School of Tropical Medicine, Baylor College of Medicine; Director, Sabin Vaccine Institute Texas Children’s Hospital Center for Vaccine Development; and President, Sabin Vaccine Institute. He also is an inventor on several patents: 5,527,937 “Hookworm Anticoagulant”; 5,753,787 “Nucleic Acids for Ancylostoma Secreted Proteins”; 7,303,752 B2 “Hookworm vaccine”; 12/492,734 “Human Hookworm Vaccine”; 61/077,256 “Multivalent Anthelminthic Vaccine”; and PCT-20100701/0.20.5.18 “Malaria Transmission blocking vaccine”. G A Mensah is a former employee of PepsiCo. F Perez-Ruiz was an adviser for Ardea, Menarini, Novartis, and Metabolex; was a member of the Speaker’s Bureau for Menarini, Novartis; an adviser for educational issues for Savient; led an investigation grants for the Spanish Health Ministry, Hospital de Cruces Rheumatology Association; and was principal investigator in clinical trials for Ardea.

Figures

Figure 1:

Figure 1:. Percentage of global deaths for female and male individuals in 1990 and 2010 by cause and age

(A) Male individuals, 1990. (B) Female individuals, 1990. (C) Male individuals, 2010. (D) Female individuals, 2010. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 2:

Figure 2:. Pie chart of global neonatal, post-neonatal, and child deaths in 2010 for children of both sexes combined by cause

(A) Age 0–27 days (neonatal); 2 840 157 total deaths. (B) Age 28–364 days (post-neonatal); 2 031 474 total deaths. (C) Age 1–4 years; 1 969 567 total deaths. ETEC=enterotoxigenic Escherichia coli. EPEC=enteropathogenic E coli. Hib=Haemophilus influenzae type B. RSV=respiratory syncytial virus.

Figure 3:

Figure 3:. Global deaths in 2010 for individuals aged 15–49 years

(A) Female individuals, 3 496 480 total deaths. (B) Male individuals, 5 741 344 total deaths. CKD=chronic kidney disease.

Figure 4:

Figure 4:. Global death ranks with 95% UIs for the top 25 causes in 1990 and 2010, and the percentage change with 95% UIs between 1990 and 2010

UI=uncertainty interval. COPD=chronic obstructive pulmonary disease. *Includes birth asphyxia/trauma. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 5:

Figure 5:

Percentage of global years of life lost (YLLs) from 1990 to 2010 for all ages and both sexes combined by cause and year

Figure 6:

Figure 6:. Global years of life lost (YLLs) ranks with 95% UIs for the top 25 causes in 1990 and 2010, and the percentage change with 95% UIs between 1990 and 2010

YLLs=years of life lost. UI=uncertainty interval. COPD=chronic obstructive pulmonary disease. *Includes birth asphyxia/trauma. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 7:

Figure 7:. Global YLLs (millions) with 95 % uncertainty intervals versus rank by cause in 2010

YLLs=years of life lost. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 8:

Figure 8:. Percentage of YLLs for all ages and both sexes combined by cause and region in 1990 and 2010

YLLs=years of life lost. (A) 1990. (B) 2010. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 9:

Figure 9:. Regional ranking of leading causes of years of life lost (YLLs), 2010

Causes in the figure are ordered according to global ranks for causes. The figure shows all causes that are in the 25 leading causes in at least one region. Ranks are also colour-shaded to indicate rank intervals. *Includes birth asphyxia/trauma. An interactive version of this figure is available online at

http://healthmetricsandevaluation.org/gbd/visualizations/regional

.

Figure 10:

Figure 10:

Cancer death rates in 2010 for all ages and both sexes combined by cause and region

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