The evolutionary landscape of alternative splicing in vertebrate species - PubMed (original) (raw)

Comparative Study

. 2012 Dec 21;338(6114):1587-93.

doi: 10.1126/science.1230612.

Manuel Irimia, Qun Pan, Hui Y Xiong, Serge Gueroussov, Leo J Lee, Valentina Slobodeniuc, Claudia Kutter, Stephen Watt, Recep Colak, TaeHyung Kim, Christine M Misquitta-Ali, Michael D Wilson, Philip M Kim, Duncan T Odom, Brendan J Frey, Benjamin J Blencowe

Affiliations

Comparative Study

The evolutionary landscape of alternative splicing in vertebrate species

Nuno L Barbosa-Morais et al. Science. 2012.

Abstract

How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species.

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