The evolutionary landscape of alternative splicing in vertebrate species - PubMed (original) (raw)
Comparative Study
. 2012 Dec 21;338(6114):1587-93.
doi: 10.1126/science.1230612.
Manuel Irimia, Qun Pan, Hui Y Xiong, Serge Gueroussov, Leo J Lee, Valentina Slobodeniuc, Claudia Kutter, Stephen Watt, Recep Colak, TaeHyung Kim, Christine M Misquitta-Ali, Michael D Wilson, Philip M Kim, Duncan T Odom, Brendan J Frey, Benjamin J Blencowe
Affiliations
- PMID: 23258890
- DOI: 10.1126/science.1230612
Comparative Study
The evolutionary landscape of alternative splicing in vertebrate species
Nuno L Barbosa-Morais et al. Science. 2012.
Abstract
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species.
Comment in
- Evolution. Splicing in 4D.
Papasaikas P, Valcárcel J. Papasaikas P, et al. Science. 2012 Dec 21;338(6114):1547-8. doi: 10.1126/science.1233219. Science. 2012. PMID: 23258879 No abstract available.
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