Novel framework for assessing epidemiologic effects of influenza epidemics and pandemics - PubMed (original) (raw)

Novel framework for assessing epidemiologic effects of influenza epidemics and pandemics

Carrie Reed et al. Emerg Infect Dis. 2013 Jan.

Abstract

The effects of influenza on a population are attributable to the clinical severity of illness and the number of persons infected, which can vary greatly between seasons or pandemics. To create a systematic framework for assessing the public health effects of an emerging pandemic, we reviewed data from past influenza seasons and pandemics to characterize severity and transmissibility (based on ranges of these measures in the United States) and outlined a formal assessment of the potential effects of a novel virus. The assessment was divided into 2 periods. Because early in a pandemic, measurement of severity and transmissibility is uncertain, we used a broad dichotomous scale in the initial assessment to divide the range of historic values. In the refined assessment, as more data became available, we categorized those values more precisely. By organizing and prioritizing data collection, this approach may inform an evidence-based assessment of pandemic effects and guide decision making.

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Figures

Figure 1

Figure 1

Estimates of influenza deaths in the 2010 United States population (308,745,538 persons) across varying values of case-fatality ratio and the cumulative incidence of infection in the population. Selected estimated numbers of deaths are indicated with a black line, across each relevant combination of case-fatality ratio and cumulative incidence. In addition, the background color transitions from blue to yellow to red as the estimated absolute number of deaths increases.

Figure 2

Figure 2

Framework for the initial assessment of the effects of an influenza pandemic.

Figure 3

Figure 3

Framework for the refined assessment of the effects of an influenza pandemic, with scaled examples of past pandemics and past influenza seasons. Color scheme included to represent corresponding estimates of influenza deaths in the 2010 US population as shown in Figure 1.

Figure 4

Figure 4

Framework for the refined assessment of the effects of an influenza pandemic, stratified by age group with scaled examples from the 2009 pandemic. Color scheme included to represent corresponding estimates of influenza deaths in the 2010 US population as shown in Figure 1.

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References

    1. Glezen WP. Emerging infections: pandemic influenza. Epidemiol Rev. 1996;18:64–76 and. 10.1093/oxfordjournals.epirev.a017917 - DOI - PubMed
    1. Fiore AE, Uyeki TM, Broder K, Finelli L, Euler GL, Singleton JA, et al. Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep. 2010;59(RR-8):1–62 . - PubMed
    1. Cox NJ, Subbarao K. Global epidemiology of influenza: past and present. Annu Rev Med. 2000;51:407–21 and. 10.1146/annurev.med.51.1.407 - DOI - PubMed
    1. Centers for Disease Control and Prevention. Interim pre-pandemic planning guidance: community strategy for pandemic influenza mitigation in the United States, February 2007. [cited 2012 Nov 19]. http://www.flu.gov/planning-preparedness/community/community_mitigation.pdf
    1. Reed C, Angulo FJ, Swerdlow DL, Lipsitch M, Meltzer MI, Jernigan D, et al. Estimates of the prevalence of pandemic (H1N1) 2009, United States, April–July 2009. Emerg Infect Dis. 2009;15:2004–7 and. 10.3201/eid1512.091413 - DOI - PMC - PubMed

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