Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome - PubMed (original) (raw)

Randomized Controlled Trial

Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome

Roberta F Carvalho et al. Vasc Health Risk Manag. 2012.

Abstract

Background: Animal studies have suggested beneficial effects of conjugated linoleic acid (CLA) in reducing body fat mass and improvement in the serum lipid profile and glycemia. However, these effects are controversial in humans. The purpose of this study was to investigate the effects of microencapsulated CLA supplementation on body composition, body mass index, waist circumference, and blood pressure in sedentary women with metabolic syndrome.

Methods: This study was a placebo-controlled and randomized clinical trial. Fourteen women diagnosed with metabolic syndrome received light strawberry jam enriched or not with microencapsulated CLA (3 g/day) as a mixture of 38.57% cis-9, trans-11, and 39.76% trans-10, cis-12 CLA isomers associated with a hypocaloric diet for 90 days. The subjects were monitored to assess variables associated with the metabolic syndrome, in addition to assessing adherence with the intervention.

Results: There were no significant effects of microencapsulated CLA on the lipid profile or blood pressure. Mean plasma insulin concentrations were significantly lower in women supplemented with microencapsulated CLA (Δ T₉₀ - T₀ = -12.87 ± 4.26 μU/mL, P = 0.02). Microencapsulated CLA supplementation did not alter the waist circumference, but there was a reduction in body fat mass detected after 30 days (Δ = -2.68% ± 0.82%, P = 0.02), which was maintained until the 90-day intervention period (Δ = -3.32% ± 1.41%, P = 0.02) in the microencapsulated CLA group. The placebo group showed this effect only after 90 days (Δ = -1.97% ± 0.60%, P = 0.02), but had a reduced waist circumference (Δ T₉₀ - T₀ = -4.25 ± 1.31 cm, P = 0.03).

Conclusion: Supplementation with mixed-isomer microencapsulated CLA may have a favorable effect on glycemic control and body fat mass loss at an earlier time in sedentary women with metabolic syndrome, although there were no effects on lipid profile and blood pressure.

Keywords: body composition; cardiovascular disease; conjugated linoleic acid; metabolic syndrome.

PubMed Disclaimer

Figures

Figure 1

Percentage change in body fat in subjects administered placebo or microencapsulated CLA during 90 days. Notes: Values are means with 95% confidence intervals (n = 14) and were measured at the same time points for all two groups (ie, day 0, 30, 60 and 90). Intervals not including 0 are significant in the CLA group and only at day 90 in the placebo group. Abbreviation: CLA, conjugated linoleic acid.

Cited by

Effect of conjugated linoleic acid on blood pressure: a meta-analysis of randomized, double-blind placebo-controlled trials.
Yang J, Wang HP, Zhou LM, Zhou L, Chen T, Qin LQ. Yang J, et al. Lipids Health Dis. 2015 Feb 18;14:11. doi: 10.1186/s12944-015-0010-9. Lipids Health Dis. 2015. PMID: 25889408 Free PMC article.
Dietary strategies to reduce metabolic syndrome.
Andersen CJ, Fernandez ML. Andersen CJ, et al. Rev Endocr Metab Disord. 2013 Sep;14(3):241-54. doi: 10.1007/s11154-013-9251-y. Rev Endocr Metab Disord. 2013. PMID: 23943309 Review.
The major European dietary patterns and metabolic syndrome.
Martínez-González MÁ, Martín-Calvo N. Martínez-González MÁ, et al. Rev Endocr Metab Disord. 2013 Sep;14(3):265-71. doi: 10.1007/s11154-013-9264-6. Rev Endocr Metab Disord. 2013. PMID: 23979531 Review.
Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives.
den Hartigh LJ. den Hartigh LJ. Nutrients. 2019 Feb 11;11(2):370. doi: 10.3390/nu11020370. Nutrients. 2019. PMID: 30754681 Free PMC article. Review.
Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial.
Mądry E, Malesza IJ, Subramaniapillai M, Czochralska-Duszyńska A, Walkowiak M, Miśkiewicz-Chotnicka A, Walkowiak J, Lisowska A. Mądry E, et al. Nutrients. 2020 Jun 17;12(6):1811. doi: 10.3390/nu12061811. Nutrients. 2020. PMID: 32560516 Free PMC article. Clinical Trial.

References

1. Athyros VG, Ganotakis ES, Elisaf MS, Liberopoulos EN, Goudevenos IA, Karagiannis A. Prevalence of vascular disease in metabolic syndrome using three proposed definitions. Int J Cardiol. 2007;117:204–210. - PubMed
1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–1645. - PubMed
1. National Cholesterol Education Program; National Heart, Lung and Blood Institute; National Institutes of Health. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Circulation. 2006;106:3143–3421. - PubMed
1. Yanagita T, Nagao K. Functional lipids and the prevention of the metabolic syndrome. Asia Pac J Clin Nutr. 2008;17(Suppl 1):189–191. - PubMed
1. Or-Rashid MM, Wright TC, McBride BW. Microbial fatty acid conversion within the rumen and the subsequent utilization of these fatty acids to improve the healthfulness of ruminant food products. Appl Microbiol Biotechnol. 2009;84:1033–1043. - PubMed

Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome - PubMed (original) (raw)