Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges - PubMed (original) (raw)

. 2013 Feb 1;190(3):1210-6.

doi: 10.4049/jimmunol.1202700. Epub 2012 Dec 28.

Affiliations

• PMID: 23275599
• DOI: 10.4049/jimmunol.1202700

Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges

Evan F Lind et al. J Immunol. 2013.

Abstract

Recent studies have begun to define the role of micro-RNAs in regulating the immune response. Micro-RNA155 (mir-155) has been shown to play a role in germinal center formation, T cell inflammation, and regulatory T cell development. In this study, we evaluated the role of mir-155 in cytotoxic T cell function. We report in this study that mice lacking mir-155 have impaired CD8(+) T cell responses to infections with lymphocytic choriomeningitis virus and the intracellular bacteria Listeria monocytogenes. We show by a series of adoptive transfer studies that the impaired CD8(+) T cell response to L. monocytogenes is T cell intrinsic. In addition, we observed that CD8(+) T cells lacking mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking. These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses.

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